产品名称
DSPE-PEG(2000) Folate, Avanti Research™ - A Croda Brand
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (880124X-10mg)
pkg of 1 × 1 mL (880124X-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
1 mg/mL (880124X-1mg)
10 mg/mL (880124X-10mg)
shipped in
dry ice
storage temp.
−20°C
Application
DSPE-PEG(2000) Folate(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000]) may be used in preparation of folate-conjugated liposomes and folate-modified microvesicles (MVs).
General description
DSPE-PEG(2000) Folate, also known as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000], is a functionalized PEG lipid. This lipid is added into liposomes as a targeting ligand for folate receptors, which acts as cellular surface markers for numerous solid tumors and myeloid leukemias. Folate targeted drug delivery is used an effective therapy for the treatment and imaging of various cancers and inflammatory diseases. Folate conjugates with low molecular weight and high binding affinity for folate receptors (FR) on cell surface deliver a variety of molecular complexes such as protein toxins, immune stimulants, chemotherapeutic agents, liposomes, nanoparticles, and imaging agents to pathologic cells without affecting normal tissues.
Packaging
5 mL Clear Glass Sealed Ampule (880124X-10mg)
5 mL Clear Glass Sealed Ampule (880124X-1mg)
Preparation Note
Soluble in ethanol, DMSO, and Chloroform:Methanol:Ammonia (80:20:2) at 5mg/mL
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 2 - STOT SE 3
target_organs
Eyes,Central nervous system, Liver,Kidney, Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
80.6 °F
flash_point_c
27 °C
法规信息
危险化学品
易制毒化学品（2类）
此项目有
Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation
Deng W, et al.
Nature Communications, 9(1) (2018)
Wei Deng et al.
Nature communications, 9(1), 2713-2713 (2018-07-15)
Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes
Magnetic and folate functionalization enables rapid isolation and enhanced tumor-targeting of cell-derived microvesicles
Zhang W, et al.
ACS Nano, 11(1), 277-290 (2017)
Wei Zhang et al.
ACS nano, 11(1), 277-290 (2016-12-23)
Cell-derived microvesicles (MVs), which are biogenic nanosized membrane-bound vesicles that convey bioactive molecules between cells, have recently received attention for use as natural therapeutic platforms. However, the medical applications of MV-based delivery platforms are limited by the lack of effective
Andrew R Hilgenbrink et al.
Journal of pharmaceutical sciences, 94(10), 2135-2146 (2005-09-02)
Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small molecular size and high binding affinity for cell surface folate receptors (FR), folate conjugates have
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