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878120P

Avanti

C18 Lyso PAF

Name: C18 Lyso PAF
Brand: AVANTI

Avanti Research^™ - A Croda Brand 878120P, powder

别名:

1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphocholine

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About This Item

经验公式（希尔记法）:

C₂₆H₅₆NO₆P

CAS号:

74430-89-0

分子量:

509.70

MDL编号:

MFCD00065889

UNSPSC代码:

12352211

NACRES:

NA.25

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Sigma-Aldrich

328634

1-甲基-2-吡咯烷酮

Supelco

97727-U

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Sigma-Aldrich

227056

N,N-二甲基甲酰胺

表单

powder

包装

pkg of 1 × 5 mg (878120P-5mg)

制造商/商品名称

Avanti Research^™ - A Croda Brand 878120P

脂质类型

bioactive lipids
phosphoglycerides

运输

dry ice

储存温度

−20°C

SMILES字符串

O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COCCCCCCCCCCCCCCCCCC

InChI

1S/C26H56NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-31-24-26(28)25-33-34(29,30)32-23-21-27(2,3)4/h26,28H,5-25H2,1-4H3/t26-/m1/s1

InChI key

XKBJVQHMEXMFDZ-AREMUKBSSA-N

一般描述

C18-lysoPAF, also known as 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphocholine, is a synthetic lyso-platelet activating factor (PAF). It is a precursor and metabolite of 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine (C18:0 PAF). Lyso-platelet activating factor (PAF) is synthesized from PAF acetylhydrolases by the degradation of PAF. Additionally, it is also synthesized in the remodeling pathway from 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine (1-alkyl-phosphatidylcholine) by the enzyme phospholipase.

应用

C18-lysoPAF (1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphocholine) has been used to study its effect on human eosinophil degranulation.

包装

5 mL Amber Glass Screw Cap Vial (878120P-5mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.

Hideo Shindou et al.

The Journal of biological chemistry, 282(9), 6532-6539 (2006-12-22)

Platelet-activating factor (PAF) is a potent proinflammatory lipid mediator eliciting a variety of cellular functions. Lipid mediators, including PAF are produced from membrane phospholipids by enzymatic cascades. Although a G protein-coupled PAF receptor and degradation enzymes have been cloned and

Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.

Kimberly D Dyer et al.

Journal of immunology (Baltimore, Md. : 1950), 184(11), 6327-6334 (2010-04-28)

Platelet-activating factor (PAF [1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine]) is a phospholipid mediator released from activated macrophages, mast cells, and basophils that promotes pathophysiologic inflammation. Eosinophil responses to PAF are complex and incompletely elucidated. We show in this article that PAF and its 2-deacetylated metabolite

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主要文件

C18 Lyso PAF