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Merck
CN
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文件

878114P

Avanti

C18-02:0 PC

Avanti Polar Lipids 878114P, powder

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别名:
1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine
经验公式（希尔记法）:
C28H58NO7P
CAS号:
74389-69-8
分子量:
551.74
UNSPSC代码:
12352211
NACRES:
NA.25

形式

powder

包装

pkg of 1 × 5 mg (878114P-5mg)

制造商/商品名称

Avanti Polar Lipids 878114P

脂质类型

bioactive lipids
phosphoglycerides

运输

dry ice

储存温度

−20°C

SMILES字符串

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCCCC)=O

InChI

1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1

InChI key

ZXCIEWBDUAPBJF-MUUNZHRXSA-N

相关类别

一般描述

C18-02:0 PC, also referred as 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine, is a natural platelet-activating factor. It is found in variety of cells including, basophil leucocytes, macrophages, polymorphonuclear neutrophils and monocytes and platelets.

应用

C18-02:0 PC or 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay.

生化/生理作用

C18-02:0 PC acts as a platelet-activating factor and facilitates platelet aggregation and secretion. It also plays a key role in inflammation and anaphylaxis.

包装

5 mL Clear Glass Sealed Ampule (878114P-5mg)

WGK

WGK 3

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Saki Yamaura et al.
Clinica chimica acta; international journal of clinical chemistry, 481, 184-188 (2018-03-20)
Measurement of lipoprotein-associated phospholipase A2 (Lp-PLA2) can be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of cardiovascular events. This can be performed by quantification of the protein concentration using an ELISA platform
Scott D Ryan et al.
Journal of lipid research, 49(10), 2250-2258 (2008-06-14)
The platelet-activating factor (PAF) family of glycerophospholipids accumulates in damaged brain tissue following injury. Little is known about the role of individual isoforms in regulating neuronal survival. Here, we compared the neurotoxic and neuroprotective activities of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16-PAF) and 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine

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