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形式
liquid
包装
pkg of 1 × 1 mL (878110C-5mg)
pkg of 1 × 2.5 mL (878110C-25mg)
制造商/商品名称
Avanti Polar Lipids 878110C
浓度
10 mg/mL (878110C-25mg)
5 mg/mL (878110C-5mg)
脂质类型
bioactive lipids
phosphoglycerides
运输
dry ice
储存温度
−20°C
SMILES字符串
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC)=O
InChI
1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
InChI key
HVAUUPRFYPCOCA-AREMUKBSSA-N
一般描述
C16-02:0 PC, also known as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is present in the body and it contains ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position.
应用
C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet-activating factor (PAF) is used as a substrate for the determination of platelet-activating factor-acetylhydrolase (PAF-AH) activity in plasma or serum.
生化/生理作用
Platelet-activating factor (PAF) is a pro-inflammatory agent that exhibits variety of biological and pharmacological effects. It plays a major role in initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It yields LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine) on hydrolysis by platelet-activating factor-acetylhydrolase.
包装
5 mL Clear Glass Sealed Ampule (878110C-25mg)
5 mL Clear Glass Sealed Ampule (878110C-5mg)
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
靶器官
Liver,Kidney, Respiratory system
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
危险化学品
易制毒化学品（2类）
Diana M Stafforini et al.
Free radical biology & medicine, 59, 100-107 (2012-06-05)
This article presents a radiometric assay to determine the enzymatic activity of platelet-activating factor (PAF) acetylhydrolase (PAF-AH), also known as lipoprotein-associated phospholipase A2 and phospholipase A2 group 7A. The method is based on the release of radioactively labeled acetate from
Saki Yamaura et al.
Clinica chimica acta; international journal of clinical chemistry, 481, 184-188 (2018-03-20)
Measurement of lipoprotein-associated phospholipase A2 (Lp-PLA2) can be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of cardiovascular events. This can be performed by quantification of the protein concentration using an ELISA platform
Sunil A Nankar et al.
Biochimie, 95(6), 1196-1207 (2013-02-05)
Apolipoprotein-derived peptides are promising candidates for the treatment of various inflammatory conditions and the main mechanism proposed for the protective action of these peptides includes binding to pro-inflammatory lipid mediators with high affinity and facilitating their sequestration/metabolism/clearance in the body.
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