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形式
powder
包装
pkg of 1 × 1 mg (870606P-1mg)
制造商/商品名称
Avanti Polar Lipids 870606P
脂质类型
phosphoglycerides
phospholipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC([H])=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O
InChI
1S/C29H56NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(32)36-25-27(39-29(33)21-18-19-23-31)26-38-40(34,35)37-24-22-30(2,3)4/h23,27H,5-22,24-26H2,1-4H3/t27-/m1/s1
InChI key
RKIDALSACBQVTN-HHHXNRCGSA-N
一般描述
1-棕榈酰基-2-（5-氧代戊酰基）-sn-甘油-3-磷酸胆碱（POVPC）是氧化型低密度脂蛋白（oxLDL）的衍生物，oxLDL是动脉粥样硬化病变中存在的促炎脂质。
应用
1-棕榈酰基-2-（5-氧戊酰基）-sn-甘油-3-磷酸胆碱（POVPC）已用于：
- 研究其对内皮功能和血管舒张的影响
- 作为在骨髓间充质基质细胞（MSCs）中的LRP6配体
- 作为氧化脂质，以研究不同程度脂质过氧化的膜状态是否与氧化性应激耐量有关
生化/生理作用
1-棕榈酰基-2-（5-氧代戊酰基）-sn-甘油-3-磷酸胆碱（POVPC）通过阻碍内皮一氧化氮合酶的活性和刺激内皮细胞凋亡来影响内皮功能。它与动脉硬化症的发展有关，并且可以用作动脉硬化症的有效治疗剂。
包装
5 mL透明玻璃密封安瓿（870606P-1mg）
Oxidized phospholipids are ligands for LRP6
Wang L, et al.
Bone research, 6(1), 22-22 (2018)
Diana M Stafforini et al.
Free radical biology & medicine, 59, 100-107 (2012-06-05)
This article presents a radiometric assay to determine the enzymatic activity of platelet-activating factor (PAF) acetylhydrolase (PAF-AH), also known as lipoprotein-associated phospholipase A2 and phospholipase A2 group 7A. The method is based on the release of radioactively labeled acetate from
Yifei Dong et al.
Frontiers in immunology, 11, 29-29 (2020-02-23)
Alveolar macrophages (AMs) are CD44 expressing cells that reside in the alveolar space where they maintain lung homeostasis by serving critical roles in immunosurveillance and lipid surfactant catabolism. AMs lacking CD44 are unable to bind the glycosaminoglycan, hyaluronan, which compromises
Feng-Xia Yan et al.
Journal of molecular and cellular cardiology, 112, 40-48 (2017-09-06)
Endothelial dysfunction is an early stage of atherosclerosis. We recently have shown that 25-hydroxycholesterol found in atherosclerotic lesions could impair endothelial function and vasodilation by uncoupling and inhibiting endothelial nitric oxide synthase (eNOS). 1-Palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), the oxidation product of oxidized
Clinically relevant radioresistant cells exhibit resistance to H2O2 by decreasing internal H2O2 and lipid peroxidation
Tomita K, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 40(9), 1010428318799250-1010428318799250 (2018)
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