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表单
powder
包装
pkg of 1 × 500 μg (870604P-500ug)
制造商/商品名称
Avanti Research™ - A Croda Brand 870604P
脂质类型
phosphoglycerides
phospholipids
运输
dry ice
储存温度
−20°C
一般描述
氧化1-棕榈酰基-2-花生四烯酰基-sn-甘油-3-磷酸胆碱（OxPAPC）是氧化磷脂和氧化低密度脂蛋白（LDL）生物活性成分的混合物。
应用
氧化1-棕榈酰-2-花生四烯醇-sn-甘油-3-磷酸胆碱（OxPAPC）适用于体外刺激鼠肺泡巨噬细胞。它也适用于研究其对人主动脉内皮细胞代谢重编程的作用。
生化/生理作用
氧化1-棕榈酰-2-花生四烯醇-sn-甘油-3-磷酸胆碱（OxPAPC）对人肺内皮单层细胞具有屏障保护作用。该脂质通过刺激促炎和抗炎途径诱导内皮功能障碍。OxPAPC在动脉粥样硬化病变和其他慢性炎症部位中高度积累。
包装
5 mL透明玻璃密封安瓿（870604P-500ug）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
Birukov KG, et al.
Microvascular Research, 67(1), 18-28 (2004)
Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC
Li R, et al.
Circulation Research, 98(5), 642-650 (2006)
Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury
Dubey PK, et al.
International Immunology, 29(2), 79-85 (2017)
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Hitzel J, et al.
Nature Communications, 9(1), 2292-2292 (2018)
Corinne M Spickett et al.
Free radical biology & medicine, 51(12), 2133-2149 (2011-10-11)
Phospholipids are complex and varied biomolecules that are susceptible to lipid peroxidation after attack by free radicals or electrophilic oxidants and can yield a large number of different oxidation products. There are many available methods for detecting phospholipid oxidation products
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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