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形式
powder
包装
pkg of 1 × 500 μg (870604P-500ug)
制造商/商品名称
Avanti Polar Lipids 870604P
脂质类型
phosphoglycerides
phospholipids
运输
dry ice
储存温度
−20°C
一般描述
氧化1-棕榈酰基-2-花生四烯酰基-sn-甘油-3-磷酸胆碱（OxPAPC）是氧化磷脂和氧化低密度脂蛋白（LDL）生物活性成分的混合物。
应用
氧化1-棕榈酰-2-花生四烯醇-sn-甘油-3-磷酸胆碱（OxPAPC）适用于体外刺激鼠肺泡巨噬细胞。它也适用于研究其对人主动脉内皮细胞代谢重编程的作用。
生化/生理作用
氧化1-棕榈酰-2-花生四烯醇-sn-甘油-3-磷酸胆碱（OxPAPC）对人肺内皮单层细胞具有屏障保护作用。该脂质通过刺激促炎和抗炎途径诱导内皮功能障碍。OxPAPC在动脉粥样硬化病变和其他慢性炎症部位中高度积累。
包装
5 mL透明玻璃密封安瓿（870604P-500ug）
WGK
WGK 3
Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
Birukov KG, et al.
Microvascular Research, 67(1), 18-28 (2004)
Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC
Li R, et al.
Circulation Research, 98(5), 642-650 (2006)
Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury
Dubey PK, et al.
International Immunology, 29(2), 79-85 (2017)
Corinne M Spickett et al.
Free radical biology & medicine, 51(12), 2133-2149 (2011-10-11)
Phospholipids are complex and varied biomolecules that are susceptible to lipid peroxidation after attack by free radicals or electrophilic oxidants and can yield a large number of different oxidation products. There are many available methods for detecting phospholipid oxidation products
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Hitzel J, et al.
Nature Communications, 9(1), 2292-2292 (2018)
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