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表单
powder
包装
pkg of 1 × 1 mg (870602P-1mg)
pkg of 1 × 5 mg (870602P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 870602P
运输
dry ice
储存温度
−20°C
SMILES字符串
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O
InChI
1S/C29H56NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(33)37-24-26(40-29(34)21-18-19-27(31)32)25-39-41(35,36)38-23-22-30(2,3)4/h26H,5-25H2,1-4H3,(H-,31,32,35,36)/t26-/m1/s1
InChI key
CDZVJFRXJAUXPP-AREMUKBSSA-N
一般描述
1-棕榈酰-2-戊二酰-sn-甘油-3-磷酸胆碱（PGPC） 是氧化修饰的低密度脂蛋白（oxLDL） 的一种成分。它是由一种主要的低密度脂蛋白（LDL） 磷脂 1-棕榈酰-2-戊二酰-sn-甘油-3-磷酸胆碱（PGPC）的非酶氧化合成的。
应用
1-棕榈酰-2-戊二酰-sn-甘油-3-磷酸胆碱（PGPC） 已被用于使用单分子显微镜研究其对质膜纳米平台的影响。
生化/生理作用
1-棕榈酰-2-戊二酰-sn-甘油-3-磷酸胆碱（PGPC）在培养的血管平滑肌细胞和巨噬细胞中充当炎症、增殖或凋亡的诱导剂。它在动脉粥样硬化病变中积累。
包装
5 mL透明玻璃密封安瓿（870602P-1mg）
5 mL透明玻璃密封安瓿（870602P-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells
Fruhwirth GO, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1761(9), 1060-1069 (2006)
The role of high-density lipoproteins in oxidation and inflammation
Van Lenten B, et al.
Trends in Cardiovascular Medicine, 11(3-4), 155-161 (2001)
Oxidized phospholipids inhibit the formation of cholesterol-dependent plasma membrane nanoplatforms
Brameshuber M, et al.
Biophysical Journal, 110(1), 205-213 (2016)
Alexandra Moumtzi et al.
Journal of lipid research, 48(3), 565-582 (2006-12-01)
Lipid oxidation is now thought to be an initiating and sustaining event in atherogenesis. Oxidatively fragmented phospholipids, namely 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), present in minimally modified LDL and atherosclerotic lesions, have been reported to elicit a wide range of
Oxidized Phospholipids Inhibit the Formation of Cholesterol-Dependent Plasma Membrane Nanoplatforms.
Mario Brameshuber et al.
Biophysical journal, 110(1), 205-213 (2016-01-09)
We previously developed a single-molecule microscopy method termed TOCCSL (thinning out clusters while conserving stoichiometry of labeling), which allows for direct imaging of stable nanoscopic platforms with raft-like properties diffusing in the plasma membrane. As a consensus raft marker, we
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