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表单
liquid
包装
pkg of 1 × 5 mg (with screw cap/argon/foil bag (870450O-5mg))
制造商/商品名称
Avanti Research™ - A Croda Brand 870450O
脂质类型
bioactive lipids
phosphoglycerides
运输
dry ice
储存温度
−70°C
SMILES字符串
[H]C(CO)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)CO
InChI
1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
InChI key
RCRCTBLIHCHWDZ-DOFZRALJSA-N
一般描述
2-花生四烯酰甘油（2-AG）是一种内源性大麻素，是CB1受体的内源性激动剂。与阿那达胺不同，2-AG在中央神经紧张的系统中以相对较高的水平存在。它是在小鼠和大鼠脑中发现的最丰富的单酰基甘油分子种类（~5-10 nmol/g组织）。在标准脂质提取条件下，由于其相对容易异构化为1-AG，因此脑组织中2-AG的检测变得复杂。与阿那达胺不同，2-AG的形成是钙依赖性的，并且由磷脂酶C（PLC）和二酰基甘油脂肪酶（DAGL）的活性介导。2-AG充当CB1受体的完全激动剂。在0.3 nM的浓度下，2-AG通过CB1受体依赖性机制诱导NG108-15神经母细胞瘤X胶质瘤细胞中细胞内游离钙的快速，瞬时增加。2-AG在体外被单酰基甘油脂肪酶（MAGL）、脂肪酸酰胺水解酶（FAAH）和未表征的丝氨酸水解酶ABHD6和ABHD12水解。
包装
5 mL PTFE小瓶，带螺旋盖/氩气/铝箔袋（870450O-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
T P Dinh et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10819-10824 (2002-07-24)
The endogenous cannabinoids (endocannabinoids) are lipid molecules that may mediate retrograde signaling at central synapses and other forms of short-range neuronal communication. The monoglyceride 2-arachidonoylglycerol (2-AG) meets several criteria of an endocannabinoid substance: (i) it activates cannabinoid receptors; (ii) it
S Kondo et al.
FEBS letters, 429(2), 152-156 (1998-07-03)
The molecular species compositions of monoacylglycerols obtained from various rat tissues were examined by reverse-phase high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) analyses. We confirmed that 2-arachidonoylglycerol, an endogenous cannabinoid receptor agonist, is one of the most abundant
Freek J Janssen et al.
Bioorganic & medicinal chemistry letters, 26(16), 3831-3837 (2016-07-11)
2-Arachidonoylglycerol (2-AG) is an endocannabinoid that activates the cannabinoid receptors type 1 and 2. It also serves as an important lipid precursor for the eicosanoid signaling pathway. Consequently, 2-AG is involved in many physiological functions, including anxiety, food intake, inflammation
T Sugiura et al.
The Journal of biological chemistry, 274(5), 2794-2801 (1999-01-23)
An endogenous cannabimimetic molecule, 2-arachidonoylglycerol, induces a rapid, transient increase in intracellular free Ca2+ concentrations in NG108-15 cells through a cannabinoid CB1 receptor-dependent mechanism. We examined the activities of 24 relevant compounds (2-arachidonoylglycerol, its structural analogues, and several synthetic cannabinoids).
Kwang-Mook Jung et al.
Cell metabolism, 15(3), 299-310 (2012-03-13)
The endocannabinoid system plays a critical role in the control of energy homeostasis, but the identity and localization of the endocannabinoid signal involved remain unknown. In the present study, we developed transgenic mice that overexpress in forebrain neurons the presynaptic
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