所有图片(1)
推荐产品
形式
powder
包装
pkg of 1 × 1 mg (867000P-1mg)
制造商/商品名称
Avanti Polar Lipids
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@]([H])(CCCCCCCCCCCCCC)[C@](O)([H])[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
InChI
1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42?,43-,44-,46+,47+,48+,49-,50+/m1/s1
InChI key
VQFKFAKEUMHBLV-VDYNBUGPSA-N
一般描述
αα-半乳糖基神经酰胺(KRN7000)是恒定自然杀伤T细胞(iNKT)的高亲和性糖脂配体。具有1个α-半乳糖基神经酰胺核心和1个agelasphin-9b神经酰胺核心变体。它是来自海绵的半乳糖神经酰胺(α‐GalCer)的合成同系物。由长链脂肪酰(C26)和鞘氨醇碱基(C18)组成。
应用
αα-半乳糖基神经酰胺(KRN7000)已用于自然杀伤细胞的体外刺激。适合用作骨髓来源细胞(BMDC)和原代肝细胞的脂质抗原，以便进行抗原提呈试验。也适合作为配体激活恒定自然杀伤T细胞(iNKT)。
生化/生理作用
αα-半乳糖基神经酰胺(KRN7000)给药导致辅助性T细胞(TH0)或TH2细胞因子应答。在各种体外模型中表现强效的抗肿瘤活性，比如B6黑色素瘤、结肠腺癌Colon26和肝转移瘤。
包装
5 mL棕色玻璃螺旋盖小瓶(867000P-1mg)
其他说明
未在日本市场销售
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Synthesis and Biological Activities of 5-Thio-alpha-GalCers
Bi J, et al.
ACS Medicinal Chemistry Letters, 6(4), 476-480 (2015)
N Fuji et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 6(8), 3380-3387 (2000-08-24)
Hepatic metastasis is a major clinical problem in cancer treatment. We examined antitumor activity of alpha-galactosylceramide (KRN7000) on mice with spontaneous liver metastases of reticulum cell sarcoma M5076 tumor cells (spontaneous metastasis model). In this model, all mice that were
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
Zhu L, et al.
Nature Communications, 9(1), 2812-2812 (2018)
Pivotal Advance: alpha-Galactosylceramide induces protection against lipopolysaccharide-induced shock
Sireci G, et al.
Journal of Leukocyte Biology, 81(3), 607-622 (2007)
SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection
Lu Y, et al.
Nature Immunology, 1-1 (2019)
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