推荐产品
形式
powder
包装
pkg of 1 × 1 mg (860677P-1mg)
制造商/商品名称
Avanti Polar Lipids 860677P
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
一般描述
C18神经酰胺（d18：1/18：0）是一种含有鞘氨醇和硬脂酸的合成神经酰胺。C18神经酰胺-d7（d18：1-d7 / 18：0）是神经酰胺d18：1/18：0的氘代衍生物。
应用
C18神经酰胺-d7（d18：1-d7 / 18：0）已被用作液相色谱-质谱（LC-MS）联用法中定量测定骨骼肌中C18神经酰胺的标准品。它还被用作thermo q-exactive质谱和四极杆-静电场轨道阱质谱法测定斑马鱼脑和人胚胎肾细胞系（HEK293）中C35–C39神经酰胺的标准品。
生化/生理作用
C18神经酰胺参与细胞生长的抑制。测定人血浆中神经酰胺（Cer）d18：1/16：0、Cer d18：1/18：0、Cer d18：1/24：0和Cer d18：1/24：1的水平和比率有助于冠状动脉疾病致命结果的预后。C18神经酰胺d18：1/18：0稳定的同位素形式为其临床规模的测量提供了一种经过验证的新液相色谱-串联质谱分析方法。
包装
5 mL 棕色玻璃螺旋盖小瓶 (860677P-1mg)
通常也和此产品一起购买
闪点(°F)
No data available
闪点(°C)
No data available
法规信息
美国出口管控1C298产品
Takhar Kasumov et al.
Analytical biochemistry, 401(1), 154-161 (2010-02-25)
We present an optimized and validated liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method for the simultaneous measurement of concentrations of different ceramide species in biological samples. The method of analysis of tissue samples is based on Bligh and
Paul T Reidy et al.
The Journal of physiology, 596(21), 5217-5236 (2018-09-09)
Insulin sensitivity (as determined by a hyperinsulinaemic-euglyceamic clamp) decreased 15% after reduced activity. Despite not fully returning to baseline physical activity levels, insulin sensitivity unexpectedly, rebounded above that recorded before 2 weeks of reduced physical activity by 14% after the recovery
Anna Zalewska et al.
Biomolecules, 9(12) (2019-12-19)
This is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (IR). The experiment was conducted on 20 male C57BL/6 mice
Hady Razak Hady et al.
Journal of clinical medicine, 8(12) (2019-12-18)
The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain whether in obese humans, the
Tejia Zhang et al.
Scientific reports, 9(1), 19939-19939 (2019-12-29)
Extensive characterisations of the zebrafish genome and proteome have established a foundation for the use of the zebrafish as a model organism; however, characterisation of the zebrafish lipidome has not been as comprehensive. In an effort to expand current knowledge
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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