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关于此项目
经验公式（希尔记法）:
C36H64D7NO3
化学文摘社编号:
分子量:
573.00
MDL number:
UNSPSC Code:
12352100
NACRES:
NA.25
产品名称
C18神经酰胺-d7(d18:1-d7/18:0), Avanti Research™ - A Croda Brand 860677P, powder
InChI
1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1/i2D3,4D2,6D2
InChI key
VODZWWMEJITOND-MUVBWDEFSA-N
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860677P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860677P
shipped in
dry ice
storage temp.
−20°C
Packaging
5 mL 棕色玻璃螺旋盖小瓶 (860677P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Application
C18神经酰胺-d7（d18：1-d7 / 18：0）已被用作液相色谱-质谱（LC-MS）联用法中定量测定骨骼肌中C18神经酰胺的标准品。它还被用作thermo q-exactive质谱和四极杆-静电场轨道阱质谱法测定斑马鱼脑和人胚胎肾细胞系（HEK293）中C35–C39神经酰胺的标准品。
Biochem/physiol Actions
C18神经酰胺参与细胞生长的抑制。测定人血浆中神经酰胺（Cer）d18：1/16：0、Cer d18：1/18：0、Cer d18：1/24：0和Cer d18：1/24：1的水平和比率有助于冠状动脉疾病致命结果的预后。C18神经酰胺d18：1/18：0稳定的同位素形式为其临床规模的测量提供了一种经过验证的新液相色谱-串联质谱分析方法。
General description
C18神经酰胺（d18：1/18：0）是一种含有鞘氨醇和硬脂酸的合成神经酰胺。C18神经酰胺-d7（d18：1-d7 / 18：0）是神经酰胺d18：1/18：0的氘代衍生物。
存储类别
11 - Combustible Solids
flash_point_f
No data available
flash_point_c
No data available
法规信息
美国出口管控产品
此项目有
Takhar Kasumov et al.
Analytical biochemistry, 401(1), 154-161 (2010-02-25)
We present an optimized and validated liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method for the simultaneous measurement of concentrations of different ceramide species in biological samples. The method of analysis of tissue samples is based on Bligh and
Tejia Zhang et al.
Scientific reports, 9(1), 19939-19939 (2019-12-29)
Extensive characterisations of the zebrafish genome and proteome have established a foundation for the use of the zebrafish as a model organism; however, characterisation of the zebrafish lipidome has not been as comprehensive. In an effort to expand current knowledge
Anna Zalewska et al.
Biomolecules, 9(12) (2019-12-19)
This is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (IR). The experiment was conducted on 20 male C57BL/6 mice
Paul T Reidy et al.
The Journal of physiology, 596(21), 5217-5236 (2018-09-09)
Insulin sensitivity (as determined by a hyperinsulinaemic-euglyceamic clamp) decreased 15% after reduced activity. Despite not fully returning to baseline physical activity levels, insulin sensitivity unexpectedly, rebounded above that recorded before 2 weeks of reduced physical activity by 14% after the recovery
Hady Razak Hady et al.
Journal of clinical medicine, 8(12) (2019-12-18)
The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain whether in obese humans, the
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