推荐产品
形式
powder
包装
pkg of 1 × 1 mg (860676P-1mg)
制造商/商品名称
Avanti Polar Lipids 860676P
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
一般描述
C16神经酰胺（d18:1/16:0）是一种含有鞘氨醇和棕榈酸的合成神经酰胺。它是由神经酰胺合成酶 6（CerS6）合成的。C16神经酰胺-d7（d18:1-d7/16:0）是神经酰胺d18:1/16:0的氘代衍生物。
应用
C16神经酰胺-d7(d18:1-d7/16:0)已被用作通过液相色谱-质谱（LC-MS）联用法测定骨骼肌中C16神经酰胺含量的标准品。
生化/生理作用
C16神经酰胺在细胞凋亡信号转导中起着至关重要的作用。检查人血浆中神经酰胺（Cer）d18:1/16:0、Cer d18:1/18:0、 Cer d18:1/24:0和 Cer d18:1/24:的水平及其比率有助于冠状动脉疾病致命结果的预后。一种经过验证的新液相色谱-串联质谱分析方法采用稳定同位素形式的C16神经酰胺（d18：1/16：0）进行临床规模的测量。
包装
5 mL 棕色玻璃螺旋盖小瓶 (860676P-1 mg)
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产品编号
说明
价格
闪点(°F)
No data available
闪点(°C)
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法规信息
美国出口管控1C298产品
S White-Gilbertson et al.
Oncogene, 28(8), 1132-1141 (2009-01-13)
We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces an increase of intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide, leading
Paul T Reidy et al.
The Journal of physiology, 596(21), 5217-5236 (2018-09-09)
Insulin sensitivity (as determined by a hyperinsulinaemic-euglyceamic clamp) decreased 15% after reduced activity. Despite not fully returning to baseline physical activity levels, insulin sensitivity unexpectedly, rebounded above that recorded before 2 weeks of reduced physical activity by 14% after the recovery
Anna Zalewska et al.
Biomolecules, 9(12) (2019-12-19)
This is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (IR). The experiment was conducted on 20 male C57BL/6 mice
Hady Razak Hady et al.
Journal of clinical medicine, 8(12) (2019-12-18)
The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain whether in obese humans, the
Dimple Kauhanen et al.
Analytical and bioanalytical chemistry, 408(13), 3475-3483 (2016-02-29)
Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease (CAD). We describe a validated liquid chromatography-tandem mass spectrometry
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