形式
powder
包装
pkg of 1 × 1 mg (860657P-1mg)
pkg of 1 × 5 mg (860657P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860657P
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@@](N)([H])[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
一般描述
鞘氨醇-d7是鞘氨醇的氘代衍生物。鞘氨醇是一种重要的生物活性鞘脂代谢产物。它是一种源自鞘磷脂的18碳氨基醇。鞘氨醇含有不饱和烃链。
应用
鞘氨醇-d7已被用作液相色谱-串联质谱法的内标，用于定量分析生物样品中的鞘脂。
生化/生理作用
鞘氨醇负调节细胞增殖并诱导凋亡。它具有调节磷脂酶，蛋白激酶，离子通道，大麻素受体1型（CB-1）受体和类固醇生成因子1（SF-1）受体活性的能力。鞘氨醇是用于合成乙酰胆碱的前体。
包装
5 mL棕色玻璃螺旋盖小瓶（860657P-1mg）
5 mL棕色玻璃螺旋盖小瓶（860657P-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
法规信息
美国出口管控1C298产品
the
Lipid Mediators and Their Metabolism in the Brain (2011)
Stephanie Schwalm et al.
The American journal of pathology, 187(11), 2413-2429 (2017-08-16)
Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring, and loss of kidney function. In this study, we investigated the role of sphingosine kinase-2 (SPHK2) on the progression of tubular fibrosis by
Iulia Zoicas et al.
Cells, 9(5) (2020-05-24)
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb)
Henning Carstens et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(6), 1015-1028 (2019-12-20)
Pulmonary infections with Pseudomonas aeruginosa (P. aeruginosa) or Staphylococcus aureus (S. aureus) are of utmost clinical relevance in patients with cystic fibrosis, chronic obstructive pulmonary disease, after trauma and burn, upon ventilation or in immuno-compromised patients. Many P. aeruginosa and
Irina Alecu et al.
Journal of lipid research, 58(1), 60-71 (2016-11-23)
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the inherited neuropathy, hereditary
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