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关于此项目
经验公式（希尔记法）:
C18H30D7NO2
化学文摘社编号:
分子量:
306.54
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860657P-1mg), pkg of 1 × 5 mg (860657P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@@](N)([H])[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
InChI key
WWUZIQQURGPMPG-AVMMVCTPSA-N
General description
鞘氨醇-d7是鞘氨醇的氘代衍生物。鞘氨醇是一种重要的生物活性鞘脂代谢产物。它是一种源自鞘磷脂的18碳氨基醇。鞘氨醇含有不饱和烃链。
Application
鞘氨醇-d7已被用作液相色谱-串联质谱法的内标，用于定量分析生物样品中的鞘脂。
Biochem/physiol Actions
鞘氨醇负调节细胞增殖并诱导凋亡。它具有调节磷脂酶，蛋白激酶，离子通道，大麻素受体1型（CB-1）受体和类固醇生成因子1（SF-1）受体活性的能力。鞘氨醇是用于合成乙酰胆碱的前体。
Packaging
5 mL棕色玻璃螺旋盖小瓶（860657P-1mg）
5 mL棕色玻璃螺旋盖小瓶（860657P-5mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
美国出口管控产品
此项目有
Stephanie Schwalm et al.
The American journal of pathology, 187(11), 2413-2429 (2017-08-16)
Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring, and loss of kidney function. In this study, we investigated the role of sphingosine kinase-2 (SPHK2) on the progression of tubular fibrosis by
Iulia Zoicas et al.
Cells, 9(5) (2020-05-24)
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb)
the
Lipid Mediators and Their Metabolism in the Brain (2011)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 860657P-1MG | 04061835186662 |
| 860657P-5MG | 04061835186679 |