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表单
powder
包装
pkg of 1 × 10 mg (860656P-10mg)
pkg of 1 × 5 mg (860656P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860656P
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O
InChI
1S/C22H47N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(25)21(23)20-29-30(26,27)28-19-18-24(2,3)4/h16-17,21-22,25H,5-15,18-20,23H2,1-4H3/b17-16+/t21-,22+/m0/s1
InChI key
AAERQLSYRRXFMA-FYBNUODKSA-N
一般描述
溶血鞘磷脂（Lyso SM）（d17:1）是具有长链鞘氨醇（C17碱）和亲水性磷酸胆碱的两亲性溶血磷脂。Lyso SM，也称为鞘氨酰磷酸胆碱（SPC），是在血浆中发现的鞘磷脂的脱酰形式。
生化/生理作用
溶血鞘磷脂（Lyso Sm）是一种重要的脂质介质，具有调节细胞增殖、迁移、分化、代谢和凋亡的能力。它在心血管系统、免疫系统、中枢神经紧张的系统和皮肤中具有多种功能。在少数疾病状态（例如特应性皮炎，尼曼-匹克病（NPD）和癌症）中观察到Lyso SM的浓度增加。
包装
5 mL棕色玻璃螺旋盖小瓶（860656P-10mg）
5 mL棕色玻璃螺旋盖小瓶（860656P-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Di Ge et al.
Acta pharmacologica Sinica, 39(12), 1830-1836 (2018-07-28)
Sphingosylphosphorylcholine (SPC) is a bioactive sphingolipid in blood plasma that is metabolized from the hydrolysis of the membrane sphingolipid. SPC maintains low levels in the circulation under normal conditions, which makes studying its origin and action difficult. In recent years
Hong-Wei Yue et al.
International journal of clinical and experimental medicine, 8(8), 11913-11921 (2015-11-10)
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid. It has been shown to exert multifunctional role in cell physiological regulation either as an intracellular second messenger or as an
Wei-Lien Chuang et al.
Molecular genetics and metabolism, 111(2), 209-211 (2014-01-15)
Niemann-Pick disease type B (NPD-B) is caused by a partial deficiency of acid sphingomyelinase activity and results in the accumulation of lysosomal sphingomyelin (SPM) predominantly in macrophages. Notably, SPM is not significantly elevated in the plasma, whole blood, or urine
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