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表单
powder
包装
pkg of 1 × 10 mg (860645P-10mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860645P
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCC
InChI
1S/C25H49NO3/c1-3-5-7-9-10-11-12-13-14-15-17-18-20-24(28)23(22-27)26-25(29)21-19-16-8-6-4-2/h18,20,23-24,27-28H,3-17,19,21-22H2,1-2H3,(H,26,29)/b20-18+/t23-,24+/m0/s1
InChI key
YUKGJYMYMCFXEF-VYQUXUJXSA-N
一般描述
C8-ceramide or N-octanoyl-D-erythro-sphingosine (C17 base) is a synthetic cell-permeable sphingolipid. It is a combination of C17 analog of sphingosine and octanoic acid. Ceramides are the major lipid component in the outermost layer of the skin, the stratum corneum. C8 Ceramide plays a vital role in inducing apoptotic cell death.
应用
C8 Ceramide (d17:1/8:0) has been used to induce myriocin-treated malignant melanoma cells to increase endogenous ceramide levels.
包装
5 mL Amber Glass Screw Cap Vial (860645P-10mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Y-S Lee et al.
Cell proliferation, 44(4), 320-329 (2011-06-08)
Melanoma is the most aggressive form of skin cancer, and it resists chemotherapy. Candidate drugs for effective anti-cancer treatment have been sought from natural resources. Here, we have investigated anti-proliferative activity of myriocin, serine palmitoyltransferase inhibitor, in the de novo
J P Witty et al.
Endocrinology, 137(12), 5269-5277 (1996-12-01)
Recent studies have demonstrated that ovarian follicle atresia occurs extensively before follicle selection into the avian preovulatory hierarchy, and that this process is mediated via granulosa cell apoptosis. Subsequent to follicle selection, granulosa cells are inherently resistant to apoptosis, and
Luisa Coderch et al.
American journal of clinical dermatology, 4(2), 107-129 (2003-01-30)
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis. It is generally accepted that the intercellular lipid domain
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