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Merck
CN

860645P

Avanti

C8 Ceramide (d17:1/8:0)

Avanti Research - A Croda Brand 860645P, powder

别名:

N-octanoyl-D-erythro-sphingosine (C17 base)

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About This Item

经验公式(希尔记法):
C25H49NO3
分子量:
411.66
UNSPSC代码:
12352211
NACRES:
NA.25

表单

powder

包装

pkg of 1 × 10 mg (860645P-10mg)

制造商/商品名称

Avanti Research - A Croda Brand 860645P

运输

dry ice

储存温度

−20°C

SMILES字符串

OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCC

InChI

1S/C25H49NO3/c1-3-5-7-9-10-11-12-13-14-15-17-18-20-24(28)23(22-27)26-25(29)21-19-16-8-6-4-2/h18,20,23-24,27-28H,3-17,19,21-22H2,1-2H3,(H,26,29)/b20-18+/t23-,24+/m0/s1

InChI key

YUKGJYMYMCFXEF-VYQUXUJXSA-N

一般描述

C8-ceramide or N-octanoyl-D-erythro-sphingosine (C17 base) is a synthetic cell-permeable sphingolipid. It is a combination of C17 analog of sphingosine and octanoic acid. Ceramides are the major lipid component in the outermost layer of the skin, the stratum corneum. C8 Ceramide plays a vital role in inducing apoptotic cell death.

应用

C8 Ceramide (d17:1/8:0) has been used to induce myriocin-treated malignant melanoma cells to increase endogenous ceramide levels.

包装

5 mL Amber Glass Screw Cap Vial (860645P-10mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Y-S Lee et al.
Cell proliferation, 44(4), 320-329 (2011-06-08)
Melanoma is the most aggressive form of skin cancer, and it resists chemotherapy. Candidate drugs for effective anti-cancer treatment have been sought from natural resources. Here, we have investigated anti-proliferative activity of myriocin, serine palmitoyltransferase inhibitor, in the de novo
J P Witty et al.
Endocrinology, 137(12), 5269-5277 (1996-12-01)
Recent studies have demonstrated that ovarian follicle atresia occurs extensively before follicle selection into the avian preovulatory hierarchy, and that this process is mediated via granulosa cell apoptosis. Subsequent to follicle selection, granulosa cells are inherently resistant to apoptosis, and
Luisa Coderch et al.
American journal of clinical dermatology, 4(2), 107-129 (2003-01-30)
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis. It is generally accepted that the intercellular lipid domain

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