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表单
powder
包装
pkg of 1 × 5 mg (860549P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860549P
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O
InChI
1S/C48H91NO8/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(40-56-48-47(55)46(54)45(53)43(39-50)57-48)42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h17-18,35,37,41-43,45-48,50-51,53-55H,3-16,19-34,36,38-40H2,1-2H3,(H,49,52)/
InChI key
WBOZIXHPUPAOIA-JZZPSRGZSA-N
一般描述
β-Glucosylceramides or glucocerebrosides (GlcCers) are synthesized from the glycosphingolipids by β-GlcCer synthase. They are synthesized in Golgi and endoplasmic reticulum and localized in the cytosolic side of cell membrane. GlcCers are omnipresent.
应用
C24:1 Glucosyl(β) Ceramide (d18:1/24:1(15Z)) may be used:
- as a standard hexosylceramide for hydrophilic interaction chromatography-based liquid chromatography mass spectroscopy
- to test its nuclear factor of activated T-cells (NFAT) activation
- in human natural killer T (NKT) cell potency assays
生化/生理作用
β-Glucosylceramides (β-GlcCer) levels are elevated inlevels in Gaucher′s disease, due to the deficiency of β-glucosidase. β-GlcCer participates in the inflammatory and acquired immune responses by binding mincle on myeloid cells and has immunostimulatory activity.
包装
5 mL Amber Glass Screw Cap Vial (860549P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
法规信息
监管及禁止进口产品
3-O-sulfo-beta-d-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5
Phongsisay V, et al.
Molecular Immunology, 63(2), 595-599 (2015)
Potent neutralizing anti-CD1d antibody reduces lung cytokine release in primate asthma model
Nambiar J, et al.
MAbs, 7(3), 638-650 (2015)
Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics
Han X and Cheng H
Journal of Lipid Research, 46(1), 163-175 (2005)
Intracellular metabolite beta-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity
Nagata M, et al.
Proceedings of the National Academy of Sciences of the USA, 114(16), E3285-E3294 (2017)
Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals
Von Gerichten J, et al.
Journal of Lipid Research, 58(6), 1247-1258 (2017)
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