形式
powder
包装
pkg of 1 × 10 mg (860524P-10mg)
pkg of 1 × 5 mg (860524P-5mg)
pkg of 1 × 50 mg (860524P-50mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C42H83NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h35,37,40-41,44-45H,3-34,36,38-39H2,1-2H3,(H,43,46)/b37-35+/t40-,41+/m0/s1
InChI key
ZJVVOYPTFQEGPH-AUTSUKAISA-N
一般描述
C24 神经酰胺具有 24 个碳单位的长酰基链长度。
应用
C24 神经酰胺 (d18:1/24:0) 曾被用于：
- 产生小的单层囊泡
- 作为液相色谱-质谱法中的内标物从大鼠样品中定量测定神经酰胺
- 测试其对蠕虫线粒体应激反应的影响
生化/生理作用
C24 神经酰胺诱导线粒体应激反应。在冠状动脉疾病 (CAD) 中，其水平被耗尽。然而，在阿尔茨海默病患者中观察到神经酰胺水平升高。C24 在强制降解过程中合成。介导自发性中性粒细胞死亡。
包装
5 mL 棕色玻璃螺旋盖小瓶 (860524P-10 mg)
5 mL 棕色玻璃螺旋盖小瓶 (860524P-5 mg)
5 mL 棕色玻璃螺旋盖小瓶 (860524P-50 mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
Ceramides and sphingomyelinases in senile plaques
Panchal M, et al.
Neurobiology of Disease, 65, 193-201 (2014)
Liposome Preparation for the Analysis of Lipid-Receptor Interaction and Efferocytosis
Voss OH, et al.
Current Protocols in Immunology, 120(1), 14-44 (2018)
Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides
Kauhanen D, et al.
Analytical and Bioanalytical Chemistry, 408(13), 3475-3483 (2016)
Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains
Pullmannova P, et al.
Biophysical Chemistry, 224, 20-31 (2017)
Lukáš Opálka et al.
Journal of lipid research, 61(2), 219-228 (2019-12-21)
Ceramides (Cers) with ultralong (∼32-carbon) chains and ω-esterified linoleic acid, composing a subclass called omega-O-acylceramides (acylCers), are indispensable components of the skin barrier. Normal barriers typically contain acylCer concentrations of ∼10 mol%; diminished concentrations, along with altered or missing long
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