推荐产品
表单
powder
包装
pkg of 1 × 10 mg (860517P-10mg)
pkg of 1 × 25 mg (860517P-25mg)
pkg of 1 × 5 mg (860517P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C35H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35(39)36-33(32-37)34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h28,30,33-34,37-38H,3-27,29,31-32H2,1-2H3,(H,36,39)/b30-28+/t33-,34+/m0/s1
InChI key
ICWGMOFDULMCFL-QKSCFGQVSA-N
一般描述
甲酰胺合成可通过以下两种方法进行介导：通过鞘氨醇或鞘氨醇水解的挽救途径；或通过二氢神经酰胺形成的从头途径。在结构上，神经酰胺具有鞘氨醇碱基，即通过酰胺键与脂肪酸连接的长链氨基醇。
应用
C17神经酰胺(d18:1/17:0)已被用于：
- 通过色谱与负离子电喷雾电离串联质谱联用定量测定心肌神经酰胺的内标物，
- 作为串联质谱(MS/MS)的内标物
- 作为鞘磷脂合酶2的底物
生化/生理作用
神经酰胺在调节各种细胞过程（如衰老和凋亡）中起关键作用。它们直接参与皮肤细胞的增殖和分化并调节皮肤屏障功能。基于神经酰胺的类似物是潜在的抗肿瘤药，被视为抑癌脂质。
包装
5 mL 棕色螺旋盖玻璃瓶l (860517P-10mg)
5 mL 棕色螺旋盖玻璃瓶l (860517P-25mg)
5 mL 棕色螺旋盖玻璃瓶l (860517P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Ye-Ryung Kim et al.
Experimental & molecular medicine, 51(11), 129-129 (2019-11-05)
The endoplasmic reticulum (ER) is not only important for protein synthesis and folding but is also crucial for lipid synthesis and metabolism. In the current study, we demonstrate an important role of ceramide synthases (CerS) in ER stress and NAFLD
Takuya Takeichi et al.
The Journal of clinical investigation, 130(2), 890-903 (2019-11-02)
The corneocyte lipid envelope, composed of covalently bound ceramides and fatty acids, is important to the integrity of the permeability barrier in the stratum corneum, and its absence is a prime structural defect in various skin diseases associated with defective
Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease
Longato L, et al.
Oxidative Medicine and Cellular Longevity, 2012 (2012)
André F Nascimento et al.
Life sciences, 88(23-24), 1031-1038 (2011-04-05)
Leptin resistance has been associated with cardiac lipotoxicity; however, whether leptin resistance is a risk factor associated with cardiac lipotoxicity at different time points in diet-induced obesity is unclear. The objective of this study was to evaluate this relationship. Male
Intercellular and intracellular functions of ceramides and their metabolites in skin
Cha HJ, et al.
International Journal of Molecular Medicine, 38(1), 16-22 (2016)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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