形式
powder
包装
pkg of 1 × 10 mg (860516P-10mg)
pkg of 1 × 100 mg (860516P-100mg)
pkg of 1 × 25 mg (860516P-25mg)
pkg of 1 × 5 mg (860516P-5mg)
pkg of 1 × 50 mg (860516P-50mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C34H67NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,32-33,36-37H,3-26,28,30-31H2,1-2H3,(H,35,38)/b29-27+/t32-,33+/m0/s1
InChI key
YDNKGFDKKRUKPY-TURZORIXSA-N
一般描述
神经酰胺包含鞘氨醇和脂肪酸，属于鞘脂家族。
应用
C16神经酰胺(d18:1/16:0)已用于：
- 色谱及串联质谱负离子电喷雾电离方法联用定量测定心肌神经酰胺的内标物
- 作为液相色谱-质谱(MS/MS)联用法定量测定大鼠样品中神经酰胺的内标物
- 测试其对蠕虫线粒体应激反应的影响
生化/生理作用
在慢性酒精相关性肝病（ALD）中，C16神经酰胺水平升高。通常，神经酰胺抑制线粒体功能和胰岛素信号传导。它们是细胞膜的重要组成部分，并参与脂筏（lipid raft ）的形成。C16神经酰胺的类似物（C2-C16 CCPS）是化疗中的潜在抗癌药。C16神经酰胺的水平及其与其它神经酰胺的比率被认为是预测冠状动脉疾病（CAD）的生物标志物。它与肿瘤抑制蛋白p53的DNA结合结构域相互作用，并激活p53。
包装
5 mL琥珀色玻璃螺旋盖小瓶（860516P-100mg）
5 mL琥珀色玻璃螺旋盖小瓶（860516P-10mg）
5 mL琥珀色玻璃螺旋盖小瓶（860516P-25mg）
5 mL琥珀色玻璃螺旋盖小瓶（860516P-50mg）
5 mL琥珀色玻璃螺旋盖小瓶（860516P-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
M Laura Fanani et al.
Langmuir : the ACS journal of surfaces and colloids, 34(39), 11749-11758 (2018-09-06)
Sphingosine [(2 S,3 R,4 E)-2-amino-4-octadecene-1,3-diol] is the most common sphingoid base in mammals. Ceramides are N-acyl sphingosines. Numerous small variations on this canonical structure are known, including the 1-deoxy, the 4,5-dihydro, and many others. However, whenever there is a Δ4
Aritz B García-Arribas et al.
Langmuir : the ACS journal of surfaces and colloids, 32(35), 9053-9063 (2016-08-04)
The effects of increasing amounts of palmitoylceramide (pCer) on human red blood cell lipid membranes have been studied using atomic force microscopy of supported lipid bilayers, in both imaging (bilayer thickness) and force-spectroscopy (nanomechanical resistance) modes. Membranes appeared homogeneous with
Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease
Longato L, et al.
Oxidative Medicine and Cellular Longevity, 2012 (2012)
Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides
Kauhanen D, et al.
Analytical and Bioanalytical Chemistry, 408(13), 3475-3483 (2016)
C 16-ceramide is a natural regulatory ligand of p53 in cellular stress response
Fekry B, et al.
Nature Communications, 9(1), 4149-4149 (2018)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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