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表单
powder
包装
pkg of 1 × 5 mg (860508P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860508P
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C26H51NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h19,21,24-25,28-29H,3-18,20,22-23H2,1-2H3,(H,27,30)/b21-19+/t24-,25+/m0/s1
InChI key
APDLCSPGWPLYEQ-WRBRXSDHSA-N
一般描述
C8 Ceramide is a short chain ceramide and is cell permeable.
应用
C8 Ceramide (d18:1/8:0) has been used as an internal ceramide standard in electrospray ionization. It has also been used as a substrate for ceramide kinase activity assay. It is suitable for use as a substrate for galactocerebrosidase.
生化/生理作用
C8 Ceramide has anti-tumor functionality. Synthetic liposomal C8 ceramide inhibits hepatocellular carcinoma (HCC). Addition of exogenous C8 ceramide causes necrosis in hepatocytes by decreasing ATP levels and impairing mitochondrial functionality. C8 ceramide inhibition of serine palmitoyl transferase halts de novo sphingolipid biosynthesis. It also acts as chemotherapeutic agent by increasing the reactive oxygen species in lung cancer cells.
包装
5 mL Amber Glass Screw Cap Vial (860508P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat
Arora AS, et al.
Hepatology, 25(4), 958-963 (1997)
Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells
Chang Y, et al.
International Journal of Molecular Sciences, 19(10), 3010-3010 (2018)
Preclinical evaluation of liposomal C8 ceramide as a potent anti-hepatocellular carcinoma agent
Lv H, et al.
Testing, 11(1), e0145195-e0145195 (2016)
The ORMDL/Orm-serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes
Davis DL, et al.
The Journal of Biological Chemistry, 294(13), 5146-5156 (2019)
Implementation of newborn screening for Krabbe disease: population study and cutoff determination
Orsini JJ, et al.
Clinical Biochemistry, 42(9), 877-884 (2009)
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