推荐产品
形式
powder
包装
pkg of 1 × 10 mg (860498P-10mg)
pkg of 1 × 100 mg (860498P-100mg)
pkg of 1 × 25 mg (860498P-25mg)
制造商/商品名称
Avanti Polar Lipids
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
InChI key
OTKJDMGTUTTYMP-ZWKOTPCHSA-N
一般描述
鞘氨醇（d18:0）是神经酰胺去饱和酶的底物。它是由于补充的甘氨酸向丝氨酸的相互转化而间接合成的。鞘氨醇（d18:0）分解代谢为神经酰胺。
应用
鞘氨醇（d18:0）已用于：
- 作为标准品，利用液相色谱-串联质谱法定量表皮神经酰胺
- 作为培养基补充，检测其对酵母细胞生长的效应
- 制备牛血清白蛋白脂质复合物，研究其对非溶酶体-葡萄糖基神经酰胺酶β2（GBA2）抑制作用的效应
生化/生理作用
鞘氨醇（d18:0）的水平在1型遗传性感觉神经病细胞中没有改变。在肿瘤缺氧中观察到d18:0的积累。它可用作研究微生物多样性的生物标记物。
包装
5 mL棕色玻璃螺旋盖小瓶（860498P-100mg）
5 mL棕色玻璃螺旋盖小瓶（860498P-10mg）
5 mL棕色玻璃螺旋盖小瓶（860498P-25mg）
通常也和此产品一起购买
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sunyoung Hwang et al.
Cell reports, 29(8), 2473-2488 (2019-11-21)
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain largely unknown. Here, we show that aneuploidy disrupts
Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease
Schonauer S, et al.
Test, 292(15), 6177-6189 (2017)
Altered sphingolipid metabolism induced by tumor hypoxia-new vistas in glycolipid tumor markers
Yin J, et al.
Febs Letters, 584(9), 1872-1878 (2010)
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Wang Z, et al.
The Journal of Investigative Dermatology, 133(3), 668-676 (2013)
Mirthe Muilwijk et al.
BMJ open diabetes research & care, 8(1) (2020-05-08)
People of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood. We determined ethnic differences in acylcarnitine, amino acid and sphingolipid concentrations and determined the associations with T2D. Associations
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