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表单
powder
包装
pkg of 1 × 5 mg (860497P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860497P
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[S](=O)(=O)([O-])OC.[N+]([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)(C)(C)C
InChI
1S/C21H44NO2.CH4O4S/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21(24)20(19-23)22(2,3)4;1-5-6(2,3)4/h17-18,20-21,23-24H,5-16,19H2,1-4H3;1H3,(H,2,3,4)/q+1;/p-1/b18-17+;/t20-,21+;/m0./s1
InChI key
OJPBMRHTGOLVFX-DSQFUKAXSA-M
一般描述
Trimethyl sphingosine (d18:1) or N,N,N-trimethyl-D-erythro-sphingosine (methyl sulfate salt) is a N-methylated sphingosine derivative.
生化/生理作用
Trimethyl sphingosine (TMS) is a protein kinase C inhibitor. It also regulates other protein kinases and enzymes implicated in signal transduction. TMS lowers transendothelial migration of neutrophils. It reduces platelet agglomeration at physiologic concentrations and attenuates myocardial reperfusion injury.
包装
5 mL Amber Glass Screw Cap Vial (860497P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
R Knöfler et al.
Thrombosis research, 76(4), 323-332 (1994-11-15)
We investigated the influence of N,N,N-trimethylsphingosine (TMS), a potent inhibitor of protein kinase C (PKC), on whole blood aggregation and ATP release from platelets. The preincubation with TMS at 1 microM for 2 min enhanced ATP release during arachidonic acid-induced
B Campbell et al.
Cardiovascular research, 39(2), 393-400 (1998-11-03)
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in cardiac contractile dysfunction as well as myocardial injury. These deleterious effects are due in large part to endothelial dysfunction leading to an upregulation of cell adhesion molecules
Biological Function of Gangliosides (1994)
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