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形式
powder
包装
pkg of 1 × 500 μg (860474P-500ug)
制造商/商品名称
Avanti Polar Lipids 860474P
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCCCCCCCCCCCC[C@](O)([H])[C@](N)([H])C([2H])([2H])[2H]
一般描述
1-deoxysphinganine-d3 is a deuterated compound, wherein the three protons of deoxysphinganine are replaced by deuterium. 1-deoxysphinganine is an atypical sphingoid base devoid of a 1-hydroxyl group.
生化/生理作用
1-deoxysphinganine acts as a biomarker for Type 2 diabetes. It can function as a cytotoxic lipid for insulin producing cells. 1-deoxysphinganine might exhibit toxicity to cancerous cells.
包装
5 mL Amber Glass Screw Cap Vial (860474P-500ug)
WGK
WGK 3
Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells.
Richard A Zuellig et al.
Diabetes, 63(4), 1326-1339 (2014-01-01)
Irreversible failure of pancreatic β-cells is the main culprit in the pathophysiology of diabetes, a disease that is now a global epidemic. Recently, elevated plasma levels of deoxysphingolipids, including 1-deoxysphinganine, have been identified as a novel biomarker for the disease.
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that
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