形式
powder
包装
pkg of 1 × 1 mg (860473P-1mg)
制造商/商品名称
Avanti Polar Lipids 860473P
脂质类型
bioactive lipids
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
NC[C@]([H])(O)CCCCCCCCCCCCCCC
一般描述
1-desoxymethylsphinganine is synthesized by the condensation of alanine with palmitoyl-CoA.
应用
1-desoxymethylsphinganine is suitable for use for testing its cytotoxic effects on primary neuron-glia cultures. It is also suitable for use as a neurotoxic agent in human CD8+ T cells. In hereditary sensory and autonomic neuropathy type I, mutations in serine palmitoyltransferase long chain base subunit 1 resulting in altered substrate specificity and accumulation of 1.
生化/生理作用
1-desoxymethylsphinganine is neurotoxic towards CD8+ T cells and inhibits cytokine production. However, it is not cytotoxic to dopaminergic neurons.
包装
5 mL Amber Glass Screw Cap Vial (860473P-1mg)
WGK
WGK 3
Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I
Rotthier A, et al.
American Journal of Human Genetics, 87(4), 513-522 (2010)
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
Wu J, et al.
Immunity, 50(5), 1218-1231 (2019)
Biophysical properties of novel 1-deoxy-(dihydro) ceramides occurring in mammalian cells
Jimenez-Rojo N, et al.
Biophysical Journal, 107(12), 2850-2859 (2014)
Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
Martinez TN, et al.
Mol. Neurodegener., 7(1), 45-45 (2012)
Nicholas C Zitomer et al.
The Journal of biological chemistry, 284(8), 4786-4795 (2008-12-20)
Fumonisin B(1) (FB(1)) is a mycotoxin that inhibits ceramide synthases (CerS) and causes kidney and liver toxicity and other disease. Inhibition of CerS by FB(1) increases sphinganine (Sa), Sa 1-phosphate, and a previously unidentified metabolite. Analysis of the latter by
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