表单
powder
包装
pkg of 1 × 1 mg (860466P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860466P
脂质类型
sphingolipids
bioactive lipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@](/C=C/CCCCCCCCCCCCC)(O)CNC(CCCCCCCCCCC)=O
InChI key
NQTIAYDGVUCKFJ-KSPVXFDASA-N
一般描述
Desoxymethylsphingosine is an atypical deoxy-sphingoid base.
应用
N-C12-desoxymethylsphingosine or N-lauroyl-1-desoxymethylsphingosine (m17:1/12:0) has been used as a standard in the quantitation of atypical sphingoid bases in biological samples by reverse-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-MS/MS).
包装
5 mL Amber Glass Screw Cap Vial (860466P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
Michael S Marshall et al.
PloS one, 13(2), e0193438-e0193438 (2018-02-27)
α-Synuclein aggregation has been linked to Gaucher's disease (GD) and Krabbe's disease (KD), lysosomal conditions affecting glycosphingolipid metabolism. α-Synuclein pathology has been directly attributed to the dysregulation of glycosphingolipids in both conditions, specifically to increased galactosylsphingosine (psychosine) content in the
Michael S Marshall et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 26(3), 874-889 (2018-02-13)
We report a global adeno-associated virus (AAV)9-based gene therapy protocol to deliver therapeutic galactosylceramidase (GALC), a lysosomal enzyme that is deficient in Krabbe's disease. When globally administered via intrathecal, intracranial, and intravenous injections to newborn mice affected with GALC deficiency
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that
Sarah T Pruett et al.
Journal of lipid research, 49(8), 1621-1639 (2008-05-24)
"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now
Terina N Martinez et al.
Molecular neurodegeneration, 7, 45-45 (2012-09-15)
Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson's disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to neuroinflammatory stimuli. Chronic inhibition of soluble Tumor Necrosis Factor (TNF) with
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