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860464P

Avanti

N-C24:1-deoxysphinganine

Avanti Research™ - A Croda Brand 860464P, powder

别名:

N-nervonoyl-1-deoxysphinganine (m18:0/24:1)

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About This Item

经验公式（希尔记法）:
C42H83NO2
CAS号:
1246298-60-1
分子量:
634.11
MDL编号:
MFCD22416693
UNSPSC代码:
12352211
NACRES:
NA.25

表单

powder

包装

pkg of 1 × 1 mg (860464P-1mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 860464P

脂质类型

sphingolipids
bioactive lipids

运输

dry ice

储存温度

−20°C

SMILES字符串

C[C@]([H])(NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

InChI key

XBNZFPFCTSJHRI-FIIAPBGQSA-N

相关类别

一般描述

1-deoxysphinganine is an atypical sphingoid base, which lacks a 1-hydroxyl group.

应用

N-C24:1-deoxysphinganine or N-nervonoyl-1-deoxysphinganine (m18:0/24:1) has been used as a standard in the quantitation of  atypical sphingoid bases in biological samples by reverse-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-MS/MS).

生化/生理作用

1-deoxysphinganine might be toxic to cancer cells. It is a potential biomarker for type 2 diabetes. 1-deoxysphinganine acts as a cytotoxic lipid for insulin producing cells.

包装

5 mL Amber Glass Screw Cap Vial (860464P-1mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Richard A Zuellig et al.
Diabetes, 63(4), 1326-1339 (2014-01-01)
Irreversible failure of pancreatic β-cells is the main culprit in the pathophysiology of diabetes, a disease that is now a global epidemic. Recently, elevated plasma levels of deoxysphingolipids, including 1-deoxysphinganine, have been identified as a novel biomarker for the disease.
Noemi Jiménez-Rojo et al.
Biophysical journal, 107(12), 2850-2859 (2014-12-18)
Ceramides and dihydroceramides are N-acyl derivatives of sphingosine and sphinganine, respectively, which are the major sphingoid-base backbones of mammals. Recent studies have found that mammals, like certain other organisms, also produce 1-deoxy-(dihydro)ceramides (1-deoxyDHCers) that contain sphingoid bases lacking the 1-hydroxyl-
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that
Sarah T Pruett et al.
Journal of lipid research, 49(8), 1621-1639 (2008-05-24)
"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now

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