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安全信息

860355P

Avanti

16:0 PC-d62

Avanti Polar Lipids 860355P, powder

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别名:
1,2-dipalmitoyl-d62-sn-glycero-3-phosphocholine
经验公式（希尔记法）:
C40H18NO8PD62
CAS号:
25582-63-2
分子量:
796.42
UNSPSC代码:
12352100
NACRES:
NA.25

检测方案

>99% (TLC)

形式

powder

包装

pkg of 1 × 10 mg (860355P-10mg)
pkg of 1 × 100 mg (860355P-100mg)
pkg of 1 × 200 mg (860355P-200mg)
pkg of 1 × 25 mg (860355P-25mg)

制造商/商品名称

Avanti Polar Lipids 860355P

运输

dry ice

储存温度

−20°C

SMILES字符串

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)COC(C([2H])([2H

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1/i1D3,2D3,6D2,7D2,8D2,9D2,10D2,11D2,12D2,13D2,14D2,15D2,16D2,17D2,18D2,19D2,20D2,21D2,22D2,23D2,24D2,25D2,26D2,27D2,28D2,29D2,30D2,31D2,32D2,33D2

InChI key

KILNVBDSWZSGLL-PWXLRKPBSA-N

相关类别

一般描述

16:0 PC-d62 is a deuterated phosphocholine (PC) in which 62 protons of dipalmitoyl are replaced by deuterium.
Deuterated fatty acids experience exchange of the deuteriums on the alpha carbon to the carbonyl, i.e., C2 position, and will therefore be a mixture of compounds that are fully deuterated and partially deuterated at that position.

应用

16:0 PC-d62 may be used for the preparation of asymmetric large unilamellar vesicles (aLUVs) for use as cell membrane models.

包装

5 mL Amber Glass Screw Cap Vial (860355P-100mg)
5 mL Amber Glass Screw Cap Vial (860355P-10mg)
5 mL Amber Glass Screw Cap Vial (860355P-200mg)
5 mL Amber Glass Screw Cap Vial (860355P-25mg)

法规信息

美国出口管控1C298产品

分析证书(COA)

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Preparation of asymmetric phospholipid vesicles for use as cell membrane models
Doktorova M, et al.
Nature Protocols, 13(9), 2086-2101 (2018)
Kalliopi-Kelli A Vandera et al.
Molecular pharmaceutics, 17(7), 2354-2369 (2020-05-01)
Gram-negative bacteria possess numerous defenses against antibiotics, due to the intrinsic permeability barrier of their outer membrane (OM), explaining the recalcitrance of some common and life-threatening infections. We report the formulation of a new drug, PPA148, which shows promising activity
Drew Marquardt et al.
Langmuir : the ACS journal of surfaces and colloids, 33(15), 3731-3741 (2017-01-21)
We measured the transbilayer diffusion of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in large unilamellar vesicles, in both the gel (Lβ') and fluid (Lα) phases. The choline resonance of headgroup-protiated DPPC exchanged into the outer leaflet of headgroup-deuterated DPPC-d13 vesicles was monitored using 1H
Benjamin Martial et al.
The journal of physical chemistry. B, 124(17), 3469-3481 (2020-04-02)
α-Synuclein (AS), the protein responsible for Parkinson's disease, contains a 12-residue-long sequence, AS71-82, that is thought to play a crucial role in the α-synuclein aggregation process. Neuronal membranes are direct interacting partners of α-synuclein and play a role in fibrillogenesis
Mitchell DiPasquale et al.
Biochimica et biophysica acta. Biomembranes, 1862(8), 183189-183189 (2020-01-19)
The antioxidant vitamin E is a commonly used vitamin supplement. Although the multi-billion dollar vitamin and nutritional supplement industry encourages the use of vitamin E, there is very little evidence supporting its actual health benefits. Moreover, vitamin E is now
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Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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