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Merck
CN

860061P

Avanti

鸡蛋 SM

Avanti Research - A Croda Brand

别名:

16:0 SM;十六烷酰鞘磷脂; N-十六烷酰基-D-赤型鞘氨酰基磷酰胆碱; N-(十六烷酰基)-鞘氨醇-1-磷酸胆碱

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About This Item

UNSPSC代码:
12352211
NACRES:
NA.25

描述

Sphingomyelin (Egg, Chicken)

检测方案

>99% (TLC)

形式

powder

包装

pkg of 1 × 1 g (860061P-1g)
pkg of 1 × 200 mg (860061P-200mg)
pkg of 1 × 25 mg (860061P-25mg)

制造商/商品名称

Avanti Research - A Croda Brand

脂质类型

sphingolipids

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C39H79N2O6P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-38(42)37(36-47-48(44,45)46-35-34-41(3,4)5)40-39(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h30,32,37-38,42H,6-29,31,33-36H2,1-5H3,(H-,40,43,44,45)/b32-30+/t37-,38+/m0/s1

InChI key

RWKUXQNLWDTSLO-GWQJGLRPSA-N

一般描述

作为细胞膜的主要成分,鞘磷脂在神经细胞(髓鞘)膜和红细胞膜中的浓度特别高。以前认为,它是因鞘氨醇碱基的2-酰胺基、3-羟基和4,5-反式双键介导的分子间相互作用而具有与磷脂酰胆碱功能相似的纯结构作用。但是,现在人们认识到,鞘磷脂对胆固醇具有高亲和力,这两种脂质在液体无序相中紧密堆积成液体有序结构域,形成脂质筏。这些膜微结构域被认为是调节蛋白质定位和相互作用的信号转导平台。但是,鞘磷脂不仅是会影响信号传导的脂质筏成分,它还是神经酰胺和其他鞘脂代谢(包括鞘磷脂循环或鞘脂网络)产物的前体。
鞘磷脂和相关脂质

应用

蛋黄SM可用于制备鞘磷脂(SM)标准溶液。还可用于制备脂质体。

包装

20 mL透明玻璃螺旋盖样品瓶(860061P-1g)
5 mL棕色玻璃螺旋盖样品瓶(860061P-200mg)
5 mL棕色玻璃螺旋盖样品瓶(860061P-25mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids


分析证书(COA)

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Visualization of the two-step fusion process of the retrovirus avian sarcoma/leukosis virus by cryo-electron tomography
Cardone G, et al.
Journal of Virology, 86(22), 12129-12137 (2012)
Maia Kinnebrew et al.
eLife, 8 (2019-10-29)
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to control a signaling
Protocols for Enzymatic Fluorometric Assays to Quantify Phospholipid Classes
Morita S, et al.
International Journal of Molecular Sciences, 21(3), 1032-1032 (2020)
Takaaki Matsufuji et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 465-471 (2017-12-13)
Ceramide is a bioactive lipid with important roles in several biological processes including cell proliferation and apoptosis. Although 3-ketoceramides that contain a keto group in place of the 3-OH group of ceramide occur naturally, ceramide derivatives oxidized at the primary
Yuanqing Ma et al.
Biophysical journal, 115(8), 1498-1508 (2018-10-03)
Membrane viscosity and hydration levels characterize the biophysical properties of biological membranes and are reflected in the rate and extent of solvent relaxation, respectively, of environmentally sensitive fluorophores such as Laurdan. Here, we first developed a method for a time-resolved

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