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Merck
CN

860061C

Avanti

Egg SM

Avanti Research™ - A Croda Brand

别名:

16:0 SM; Hexadecanoyl Sphingomyelin; N-hexadecanoyl-D-erythro-sphingosylphosphorylcholine; N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine

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关于此项目

化学文摘社编号:
383907-87-7
MDL number:
MFCD02259286
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

Egg SM, Avanti Research™ - A Croda Brand

SMILES string

[P](=O)([O-])(OC[C@H](NC(=O)CCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C39H79N2O6P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-38(42)37(36-47-48(44,45)46-35-34-41(3,4)5)40-39(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h30,32,37-38,42H,6-29,31,33-36H2,1-5H3,(H-,40,43,44,45)/b32-30+/t37-,38+/m0/s1

InChI key

RWKUXQNLWDTSLO-GWQJGLRPSA-N

description

Sphingomyelin (Egg, Chicken), chloroform

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (860061C-25mg)
pkg of 2 × 20 mL (860061C-1g)
pkg of 2 × 4 mL (860061C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (860061C-25mg)
25 mg/mL (860061C-1g)
25 mg/mL (860061C-200mg)

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

Application

Egg SM is suitable for use:
  • for preparation of liposomes
  • for synthesizing dihydrosphingomyelin (dhSM)
  • for sphingomyelin assay

General description

As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base. However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts. These membrane microdomains are thought to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.
Sphingomyelin and related lipids

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (860061C-1g)
5 mL Clear Glass Sealed Ampule (860061C-200mg)
5 mL Clear Glass Sealed Ampule (860061C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

易制毒化学品（2类）
危险化学品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Light Scattering By Optically-Trapped Vesicles Affords Unprecedented Temporal Resolution Of Lipid-Raft Dynamics
Collard L, et al.
Scientific reports, 7(1), 8589-8589 (2017)
Changes in serum sphingomyelin after Roux-en-Y gastric bypass surgery are related to diabetes status
Carlsson ER, et al.
Frontiers in Endocrinology, 9, 172-172 (2018)
A novel flow cytometric assay to quantify interactions between proteins and membrane lipids
Temmerman K and Nickel W
Journal of Lipid Research, 50(6), 1245-1254 (2009)
Maia Kinnebrew et al.
eLife, 8 (2019-10-29)
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to control a signaling
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Hernandez-Tiedra S, et al.
Autophagy, 12(11), 2213-2229 (2016)
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