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安全信息

860042P

Avanti

16:0-d31-18:1 PI

1-palmitoyl-d31-2-oleoyl-sn-glycero-3-phosphoinositol (ammonium salt), powder

别名:

110923

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About This Item

经验公式（希尔记法）:
C43H53NO13PD31
CAS号:
799812-61-6
分子量:
885.29
UNSPSC代码:
51191904
NACRES:
NA.25

方案

>99% (TLC)

表单

powder

包装

pkg of 1 × 100 μg (with stopper and crimp cap (860042P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (860042P-500ug))

制造商/商品名称

Avanti Research™ - A Croda Brand 860042P

运输

dry ice

储存温度

−20°C

SMILES字符串

[NH4+].[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(=O)OC[C@H](COP([O-])(=O)O[C@H]1C(O)C(O)C(O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

1S/C43H81O13P.H3N/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-37(45)55-35(34-54-57(51,52)56-43-41(49)39(47)38(46)40(48)42(43)50)33-53-36(44)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2;/h17-18,35,38-43,46-50H,3-16,19-34H2,1-2H3,(H,51,52);1H3/b18-17-;/t35-,

InChI key

NPOZNLWSCICHRX-MPQXHUEUSA-N

相关类别

一般描述

16:0-d31-18:1 PI或1-棕榈酰基-d31-2-油酰基-sn-甘油-3-磷酸肌醇是氘代磷脂。该脂质由附着在棕榈酸和油酸上的磷脂酰肌醇基团组成。
氘化脂肪酸经历了α碳上的氘向羰基即C2位的交换，因此将是在该位置上完全氘化和部分氘化的化合物的混合物。

应用

16:0-d31-18:1 PI或1-棕榈酰基-d31-2-油酰基-sn-甘油-3-磷酸肌醇已用作内标：
  • 在酵母脂质谱分析中
  • 用于电喷雾电离串联质谱法（ESI-MS/MS）定量分析脂质
  • 用于Bligh和Dyer方法从人支气管组织和上皮样品中提取脂质，并用于液相色谱-质谱（LC-MS）分析

生化/生理作用

磷脂酰肌醇（PI）在其羟基上被磷酸化，磷酸化的PI调节几种生物学过程，包括膜运输，蛋白质募集和自噬。

包装

带塞子和压接盖的2 mL棕色血清瓶（860042P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（860042P-500ug）

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

法规信息

美国出口管控1C298产品

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Nicole Zehethofer et al.
Chromatographia, 78(5-6), 403-413 (2015-03-10)
Airway epithelial cells play an important role in the pathogenesis of inflammatory lung diseases such as asthma, cystic fibrosis and COPD. Studies concerning the function of the lipid metabolism of the airway epithelium are so far based only on the
G van Echten-Deckert et al.
The Journal of biological chemistry, 272(25), 15825-15833 (1997-06-20)
The effect of six different structurally modified sphingosine analogues on biosynthesis of sphingolipids was studied in primary cultured murine cerebellar neurons. Treatment of cells with cis-4-methylsphingosine at micromolar levels resulted in a markedly decreased sphingolipid biosynthesis, whereas the other compounds
Michael Ter Braak et al.
Biochemical pharmacology, 81(5), 617-625 (2010-12-18)
Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P(1-5), that play important roles e.g. in the cardiovascular and immune systems. A S1P receptor modulating drug, FTY720 (fingolimod), has been effective in phase III clinical trials for multiple
Nicholas J Blunsom et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(1), 158471-158471 (2019-06-08)
Phosphatidylinositol (PI) is a minor phospholipid with a characteristic fatty acid profile; it is highly enriched in stearic acid at the sn-1 position and arachidonic acid at the sn-2 position. PI is phosphorylated into seven specific derivatives, and individual species
Sarah Spiegel et al.
Nature reviews. Molecular cell biology, 4(5), 397-407 (2003-05-03)
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are
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