产品名称
NIBR189, Avanti Research™ - A Croda Brand 857397P, powder
SMILES string
BrC(C=C1)=CC=C1/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O
InChI
1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+
InChI key
OFHXXBRBGWUOHR-NYYWCZLTSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (857397P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857397P
shipped in
dry ice
storage temp.
−20°C
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General description
Potent and selective antagonist of the G protein-coupled receptor identified as EBI2 (GPR183) (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors, respectively). This compound exhibits selectivity for EBI2 over other receptors, enzymes and transporters. In addition, NIBR189 blocks oxysterol-induced migration of U937 monocyte cells.
Application
NIBR189 has been used to test the effects of chronic Epstein-Barr virus-induced gene 2 (EBI2) deficiency on dendritic cells (DC) numbers. It has also been used in chemotaxis assay of RAW264.7 macrophages directed towards 7β,25-dihydroxycholesterol (7β25OHC).
Biochem/physiol Actions
NIBR189 is a potent and selective antagonist of the G protein-coupled receptor (GPR183). This compound exhibits selectivity for Epstein-Barr virus-induced gene 2 (EBI2) receptor over other receptors, enzymes and transporters. NIBR189 has an IC50 value of 11 and 15 nM for human and mouse EBI2 receptors, respectively.It is known to block oxysterol.
Packaging
5 mL Amber Glass Screw Cap Vial (857397P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor
Gessier F, et al.
Journal of Medicinal Chemistry, 57(8), 3358-3368 (2014)
Distinct oxysterol requirements for positioning naive and activated dendritic cells in the spleen
Lu E, et al.
Science immunology, 2(10) (2017)
Francois Gessier et al.
Journal of medicinal chemistry, 57(8), 3358-3368 (2014-04-01)
Oxysterols have recently been identified as natural ligands for a G protein-coupled receptor called EBI2 (aka GPR183) ( Nature 2011 , 475 , 524 ; 519 ). EBI2 is highly expressed in immune cells ( J. Biol. Chem. 2006
Katharina R Beck et al.
The Journal of steroid biochemistry and molecular biology, 190, 19-28 (2019-03-25)
Oxysterols are cholesterol metabolites derived through either autoxidation or enzymatic processes. They consist of a large family of bioactive lipids that have been associated with the progression of multiple pathologies. In order to unravel (patho-)physiological mechanisms involving oxysterols, it is
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