推荐产品
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (857395P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 857395P
脂质类型
bioactive lipids
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCCCCCCCCCCCC1=C(C1)[C@@H](O)[C@@H](NC(CCCCCCC)=O)CO
InChI
1S/C28H53NO3/c1-3-5-7-9-10-11-12-13-14-15-17-18-20-24-22-25(24)28(32)26(23-30)29-27(31)21-19-16-8-6-4-2/h26,28,30,32H,3-23H2,1-2H3,(H,29,31)/t26-,28+/m0/s1
InChI key
AQFQOEPCXZMMDT-XTEPFMGCSA-N
一般描述
GT-11 is also termed as C8-cyclopropenylceramide or C8-CPPC.
生化/生理作用
GT-11 is an inhibitor of dihydroceramides (DHCer) desaturase activity.
包装
5 mL Amber Glass Screw Cap Vial (857395P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Gemma Triola et al.
Molecular pharmacology, 66(6), 1671-1678 (2004-09-17)
Dihydroceramide desaturase catalyzes the conversion of the innocuous precursor dihydroceramide into a highly bioactive product ceramide. We studied the effect of N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), the first inhibitor of this enzyme, in primary cultured cerebellar neurons. Although desaturase was efficiently inhibited (IC50
Inhibition of sphingolipid metabolism enhances resveratrol chemotherapy in human gastric cancer cells
Shin K, et al.
Biomolecules & Therapeutics, 20(5), 470-470 (2012)
Bioactive sphingolipids: An overview on ceramide, ceramide 1-phosphate dihydroceramide, sphingosine, sphingosine 1-phosphate
Handbook of Neurochemistry and Molecular Neurobiology:Neural Lipids, 373-383 (2010)
Pau Muñoz-Guardiola et al.
Autophagy, 17(6), 1349-1366 (2020-05-14)
ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and squamous non-small cell lung carcinoma (NCT03366480). Previously, we showed that ABTL0812 induces TRIB3 pseudokinase
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门