检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (857390P-1mg)
pkg of 1 × 10 mg (857390P-10mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 857390P
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
一般描述
Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.
W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.
应用
W146 has been used:
- to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
- to study oxidative stress and drug treatment in granulosa cells
- to evaluate its effects on transendothelial electrical resistance (TEER)
生化/生理作用
W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.
包装
5 mL Amber Glass Screw Cap Vial (857390P-10mg)
5 mL Amber Glass Screw Cap Vial (857390P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway
Nakahara T, et al.
Fertility and Sterility, 98(4) (2012)
The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (2014)
S1P, dihydro-S1P and C24: 1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
Argraves KM, et al.
Lipids in Health and Disease, 10(1), 70-70 (2011)
The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Tarrason G, et al.
International Immunopharmacology, 11(11), 1773-1779 (2011)
M Germana Sanna et al.
Nature chemical biology, 2(8), 434-441 (2006-07-11)
Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门