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方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (857341P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 857341P
脂质类型
phospholipids
cardiolipins
运输
dry ice
储存温度
−20°C
SMILES字符串
O=C(CCCCCCC/C=C\CCCCCCCC)N[C@H](COP(O)([O-])=O)CC1=CC=C(OCC2=CC=CC=C2)C=C1.[NH4+]
一般描述
VPC 12249 is an N-acyl (oleoyl) serine phosphate-based compound.
应用
VPC 12249 has been used as lysophosphatidic acid (LPA)1/3 receptor antagonist in various experimental studies.
生化/生理作用
Lysophosphatidic acids (LPAs) are bioactive lipid mediators. It interacts with at least six specific LPA receptors (LPA1-6) to mediate extracellular signaling pathway. LPA and its receptors (LPA1-3) are implicated in the pathogenesis of radiation pneumonitis (RP). VPC 12249 (S) inhibits the binding ofLPA to LPA1 and LPA3 receptor.
包装
5 mL Amber Glass Screw Cap Vial (857341P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
法规信息
新产品
Possible role of lysophosphatidic acid in rat model of hypoxic pulmonary vascular remodeling
Shlyonsky V, et al.
Pulmonary Circulation, 4(3), 471-481 (2014)
LPA receptor signaling: pharmacology, physiology, and pathophysiology
Yung, Y, et al.
Journal of Lipid Research, 55(7), 1192-1214 (2014)
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor
Hasegawa Y, et al.
The Journal of Biological Chemistry, 278(14), 11962-11969 (2003)
Effects of lysophosphatidic acid and its receptors LPA 1/3; on radiation pneumonitis
Xue J, et al.
Oncology Reports, 24(6), 1515-1520 (2010)
Lysophosphatidic acid inhibits insulin signaling in primary rat hepatocytes via the LPA3 receptor subtype and is increased in obesity
Fayyaz S, et al.
Cellular Physiology and Biochemistry, 43(2), 445-456 (2017)
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