检测方案
>99% (BMP (contains 30% positional isomers), TLC)
形式
liquid
包装
pkg of 1 × 1 mL (857133C-5mg)
pkg of 1 × 2 mL (857133C-50mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 857133C
浓度
25 mg/mL (857133C-50mg)
5 mg/mL (857133C-5mg)
脂质类型
cardiolipins
phospholipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP(OC[C@@]([H])(O)COC(CCCCCCC/C=C\CCCCCCCC)=O)([O-])=O)(O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]
一般描述
Bis(monoacylglycerol)phosphate (BMP), an acidic phospholipid is mostly found in the lysosomal and endosomal compartments within cells.
应用
18:1 BMP (S,R) is suitable for the analysis of Niemann-Pick C2 (NPC2)-lipid interaction.
生化/生理作用
Bis(monoacylglycerol)phosphate (BMP) plays a vital role in late endosomes/lysosomes (LE/Lys) degradation pathway. It is involved in digestion and recycling of membranous materials and synthesis of intra luminal vesicles. BMP also regulates cholesterol homeostasis and trafficking of lysosomal enzymes.
包装
5 mL Clear Glass Sealed Ampule (857133C-50mg)
5 mL Clear Glass Sealed Ampule (857133C-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
靶器官
Liver,Kidney, Respiratory system
WGK
WGK 3
法规信息
危险化学品
易制毒化学品（2类）
Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
McCauliff LA, et al.
eLife, 8 (2019)
Ion mobility and tandem mass spectrometry of phosphatidylglycerol and bis (monoacylglycerol) phosphate (BMP)
Hankin JA, et al.
International Journal of Mass Spectrometry, 378, 255-263 (2015)
Nanjun Liu et al.
Toxicology and applied pharmacology, 279(3), 467-476 (2014-06-27)
The inability to routinely monitor drug-induced phospholipidosis (DIPL) presents a challenge in pharmaceutical drug development and in the clinic. Several nonclinical studies have shown di-docosahexaenoyl (22:6) bis(monoacylglycerol) phosphate (di-22:6-BMP) to be a reliable biomarker of tissue DIPL that can be
Elena Zaitseva et al.
PLoS pathogens, 6(10), e1001131-e1001131 (2010-10-16)
Many enveloped viruses invade cells via endocytosis and use different environmental factors as triggers for virus-endosome fusion that delivers viral genome into cytosol. Intriguingly, dengue virus (DEN), the most prevalent mosquito-borne virus that infects up to 100 million people each
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