检测方案
>99% (BMP (contains 30% positional isomers), TLC)
形式
liquid
包装
pkg of 1 × 1 mL (857131C-10mg)
pkg of 1 × 1 mL (857131C-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 857131C
浓度
10 mg/mL (857131C-10mg)
5 mg/mL (857131C-5mg)
脂质类型
cardiolipins
phospholipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP(OC[C@@]([H])(O)COC(CCCCCCCCCCCCC)=O)([O-])=O)(O)COC(CCCCCCCCCCCCC)=O.[NH4+]
一般描述
Bis(monoacylglycerol) phosphate (BMP) is a phospholipid, containing two-phosphate linked fatty acid esterified glycerol molecule. It is present in late endosome, mainly in intraluminal vesicles (ILVs). BMP accounts to 15% of total organelle lipids.
应用
14:0 BMP (S,R) is suitable to use as the internal standard for lipid extractions and mass spectrometric quantification from Detergent-resistant membrane (DRM) and detergent-soluble membrane (DSM) fractions.
生化/生理作用
Bis(monoacylglycerol)phosphate (BMP) plays a key role in cargo sorting and protein and lipid trafficking. The levels of BMP is elevated in lysosomal storage disorders (LSD) including Wolman disease, Niemann Pick disease and neuronal ceroid lipofuscinoses. It is resistant to degradation by the enzyme, acid phospholipase.
包装
5 mL Clear Glass Sealed Ampule (857131C-10mg)
5 mL Clear Glass Sealed Ampule (857131C-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
靶器官
Liver,Kidney, Respiratory system
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
新产品
Lipid composition of microdomains is altered in neuronopathic Gaucher disease sheep brain and spleen
Hein LK, et al.
Molecular Genetics and Metabolism, 121(3), 259- 270 (2017)
Metabolic disease and ABHD6 alter the circulating bis (monoacylglycerol) phosphate profile in mice and humans
Grabner GF, et al.
Journal of Lipid Research, jlr-M093351 (2019)
Selective reduction of bis (monoacylglycero) phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease
Hein LK, et al.
Journal of Lipid Research, 54(6), 1691- 1697 (2013)
Roger Lawrence et al.
Molecular genetics and metabolism reports, 21, 100524-100524 (2019-11-14)
GM1 gangliosidosis is a rare autosomal recessive genetic disorder caused by the disruption of the GLB1 gene that encodes β-galactosidase, a lysosomal hydrolase that removes β-linked galactose from the non-reducing end of glycans. Deficiency of this catabolic enzyme leads to
Metabolic disease and ABHD6 alter the circulating bis (monoacylglycerol) phosphate profile in mice and humans
Grabner GF, et al.
Journal of Lipid Research, jlr-M093351 (2019)
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