描述
1-stearoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
检测方案
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
形式
powder
包装
pkg of 1 × 25 mg (857128P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
cardiolipins
phospholipids
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O.[Na+]
一般描述
溶血磷脂酸（1-或2-酰基溶血磷脂酸/LPA）是一种生物活性磷脂，血浆水平较低（~100 nM）。它通常在细胞膜磷脂合成过程中形成。它由多种细胞产生，如活化血小板、上皮细胞、白细胞、神经细胞和肿瘤细胞。18:0 Lyso PA在sn-1位有硬脂酸，在sn-2位有羟基。
应用
18:0 Lyso PA适用于：
- 色谱法测定LPA中性pH和酸性pH条件下的提取回收率
- 用作内标，研究肠源性溶血磷脂酸在血脂异常和动脉粥样硬化中的作用
- 研究其对网格蛋白依赖性内吞作用的影响
生化/生理作用
溶血磷脂酸（1-或2-酰基溶血磷脂酸/LPA）可通过G蛋白偶联受体（GPCR）调节细胞运动、增殖、侵袭、存活和生长因子的产生。
包装
5 mL棕色玻璃螺旋盖样品瓶（857128P-25mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation, 2017 (2017)
Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
Ailte I, et al.
Traffic, 18(3), 176-191 (2017)
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column
Shan L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864(1-2), 22-28 (2008)
Ieva Ailte et al.
Scientific reports, 6, 30336-30336 (2016-07-28)
Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells
Mohamad Navab et al.
Journal of lipid research, 54(12), 3403-3418 (2013-10-03)
We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic atherosclerosis in LDL receptor-null (LDLR⁻/⁻) mice fed a Western diet (WD). Here we demonstrate that WD increases unsaturated (but
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