检测方案
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
形式
powder
包装
pkg of 1 × 25 mg (857120P-25mg)
pkg of 1 × 500 mg (857120P-500mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 857120P
脂质类型
phospholipids
cardiolipins
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCC)=O.[Na+]
一般描述
溶血磷脂酸（LPA）属于磷脂类，其甘油主链由磷酸基、脂肪链和羟基连接而成。它的磷酸基连接到sn-3位，脂肪链连接到sn-1或sn-2位，羟基连接到其余sn-1或sn-2位。
应用
14:0 Lyso PA适合用作内标物以加标血清样品以提取血清脂质。它也适用于在多反应监测（MRM）分析中用作脂质提取和质量控制的标准脂质。
生化/生理作用
溶血磷脂酸（LPA）参与多种生物学功能。它是检测卵巢癌的潜在生物标志物。LPA可刺激血小板聚集、平滑肌收缩、趋化、细胞骨架重排、Ca2+动员、神经递质释放和细胞增殖。
包装
20 mL透明玻璃螺旋盖小瓶（857120P-500mg）
5 mL棕色玻璃螺旋盖小瓶（857120P-25mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells
Li L, et al.
Journal of Chromatography A, 1381(2), 140-148 (2015)
Determination of lysophosphatidic acids by capillary electrophoresis with indirect ultraviolet detection
Chen YL and Xu Y
Journal of Chromatography. B, Biomedical Sciences and Applications, 753(2), 355-363 (2001)
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column
Shan L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864(1-2), 22-28 (2008)
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Jesica R Williams et al.
The Journal of biological chemistry, 284(25), 17304-17319 (2009-04-16)
Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. Because the structure-activity relationship (SAR) of GPR92/LPA(5) is limited and whether LPA is its
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