产品名称
08:0 PE, 1,2-dioctanoyl-sn-glycero-3-phosphoethanolamine, chloroform
InChI key
UNACBKDVIYEXSL-LJQANCHMSA-N
SMILES string
[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (850699C-10mg), pkg of 1 × 2.5 mL (850699C-25mg), pkg of 1 × 20 mL (850699C-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850699C
concentration
10 mg/mL (850699C-10mg), 10 mg/mL (850699C-25mg), 25 mg/mL (850699C-500mg)
shipped in
dry ice
storage temp.
−20°C
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General description
Phosphoethanolamine (PE), a lipid chaperone, usually seen in the membrane leaflet is abundantly present in the mitochondria.
Application
08:0 PE (1,2-dioctanoyl-sn-glycero-3-phosphoethanolamine) may be used in the preparation of liposomes for conjugating with pH sensors for live cell imaging. It may also be used in the micelles for kinetic measurements studies. It has been used as a phosphoethanolamine (PE) lipid species in the lipid collision cross section (CCS) calibration mixture.
Biochem/physiol Actions
Phosphoethanolamine (PE) participates in phospholipid metabolism. It has the ability to induce nutrient starvation tolerance. PE is capable of stimulating the development of tumor. It actively participates in the production of glycosylphosphatidylinositol-anchored proteins (GPI-AP).
Packaging
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850699C-500mg)
5 mL Clear Glass Sealed Ampule (850699C-10mg)
5 mL Clear Glass Sealed Ampule (850699C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
target_organs
Liver,Kidney, Respiratory system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
危险化学品
易制毒化学品（2类）
此项目有
Tsuyoshi Osawa et al.
Cell reports, 29(1), 89-103 (2019-10-03)
Tolerance to severe tumor microenvironments, including hypoxia and nutrient starvation, is a common feature of aggressive cancer cells and can be targeted. However, metabolic alterations that support cancer cells upon nutrient starvation are not well understood. Here, by comprehensive metabolome
S K Han et al.
The Journal of biological chemistry, 272(6), 3573-3582 (1997-02-07)
Recent genetic and structural studies have shed considerable light on the mechanism by which secretory phospholipases A2 interact with substrate aggregates. Electrostatic forces play an essential role in optimizing interfacial catalysis. Efficient and productive adsorption of the Class I bovine
Jungju Yoon et al.
Advanced materials (Deerfield Beach, Fla.), 26(26), 4559-4564 (2014-05-03)
Phase separation in films of phospholipids and conjugated polymers results in nanoassemblies because of a difference in the physicochemical properties between the hydrophobic polymers and the polar lipid heads, together with the comparable polymer side-chain lengths to lipid tail lengths
Ronja Marie Kühnel et al.
The Analyst, 144(9), 3030-3037 (2019-03-23)
The design of ion sensors has gained importance for the study of ion dynamics in cells, with fluorescent proton nanosensors attracting particular interest because of their applicability in monitoring pH gradients in biological microcompartments and reconstituted membrane systems. In this
D W Ellison et al.
Brain research, 417(2), 389-392 (1987-08-11)
Measurements of both phosphoethanolamine (PEA) and ethanolamine (EA) were made in postmortem brain samples from patients with Alzheimer's disease (AD) and Huntington's disease (HD) using high-performance liquid chromatography with electrochemical detection. In AD levels of PEA were significantly reduced by
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