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方案
>99% (TLC)
表单
powder
分子量
322.91 g/mol
包装
pkg of 1 × 25 mg (850546P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 850546P
运输
dry ice
储存温度
−20°C
SMILES字符串
[NH3+][C@@H](COC)C(NCCCCCCCCCCCC)=O.[Cl-]
InChI
1S/C16H34N2O2.ClH/c1-3-4-5-6-7-8-9-10-11-12-13-18-16(19)15(17)14-20-2;/h15H,3-14,17H2,1-2H3,(H,18,19);1H/t15-;/m0./s1
InChI key
KEFSFBIMLKNBML-RSAXXLAASA-N
一般描述
O-methyl-serine-dodecylamide hydrochloride (MSDH) is a synthetic lysosomotropic detergent.
应用
MSDH is suitable is suitable to induce lysosomal membrane destabilization to investigate the mechanistic basis for Bax/Bak-mediated autophagic cell death.
生化/生理作用
O-methyl-serine-dodecylamide hydrochloride (MSDH) stimulates cell death. After apoptosis, it may activate procaspase 3-like proteases and cause partial lysosomal rupture.
包装
5 mL Amber Glass Screw Cap Vial (850546P-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Ana M Villamil Giraldo et al.
Langmuir : the ACS journal of surfaces and colloids, 32(50), 13566-13575 (2016-12-13)
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Karch J, et al.
eLife, 6, e30543-e30543 (2017)
Methylmercury and H2O2 provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
Dare E, et al.
Free radical biology & medicine, 30(12), 1347-1356 (2001)
Induction of cell death by the lysosomotropic detergent MSDH
Li W, et al.
Febs Letters, 470(1), 35-39 (2000)
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
Fucho R, et al.
Journal of Hepatology, 61(5), 1126-1134 (2014)
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