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方案
>99% (TLC)
表单
powder
分子量
796.95 g/mol
包装
pkg of 1 × 25 mg (850539P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 850539P
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@H]2OCCOP(OCC[N+](C)(C)C)([O-])=O)([H])C[C@H](OCCOP(OCC[N+](C)(C)C)([O-])=O)[C@@]4(C)[C@@]1([H])CC[C@@H]4[C@H](C)CCC
InChI
1S/C38H74N2O11P2/c1-11-12-28(2)31-13-14-32-36-33(27-35(38(31,32)4)47-22-24-51-53(44,45)49-20-18-40(8,9)10)37(3)16-15-30(41)25-29(37)26-34(36)46-21-23-50-52(42,43)48-19-17-39(5,6)7/h28-36,41H,11-27H2,1-10H3/t28-,29+,30-,31-,32+,33+,34-,35+,36+,37+,38-/m1/s
InChI key
RTNFJBQUBTXGHR-HECRFRQFSA-N
应用
Facade™-EPC has been used to produce bicelles for nuclear magnetic resonance (NMR) experiments. It may be used in crystallization of cytochrome P450 2B subfamily proteins, CYP2B35 and CYP2B37.
生化/生理作用
Facade™ EPC/FA-7 (3α-hydroxy-7α,12α-di-(((2-(trimethylamino)ethyl)phosphoryl)ethyloxy)-cholane) having phosphocholine groups helps in preparing smaller micelles than the facial amphiphiles (FAs) with nonionic sugar groups.
Facade™ is a mild rim forming surfactants, used in the synthesis of isotropic bicelles which prevents unfolding of soluble globular domains of large membrane proteins.
包装
5 mL Amber Glass Screw Cap Vial (850539P-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
法规信息
新产品
Faccade detergents as bicelle rim-forming agents for solution NMR spectroscopy
Mineev KS, et al.
Nanotechnology Reviews, 6(1), 93-103 (2017)
Structure-function analysis of mammalian CYP2B enzymes using 7-substituted coumarin derivatives as probes: utility of crystal structures and molecular modeling in understanding xenobiotic metabolism
Shah MB, et al.
Molecular Pharmacology, 89(4), 435-445 (2016)
Phase Transitions in Small Isotropic Bicelles
Kot EF, et al.
Langmuir, 34(11), 3426-3437 (2018)
Sung Chang Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), E1203-E1211 (2013-03-13)
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from conventional detergents and previously developed FAs. The unique FAs stabilize MPs and
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Qinghai Zhang et al.
Angewandte Chemie (International ed. in English), 46(37), 7023-7025 (2007-08-11)
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