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经验公式（希尔记法）:
C42H82NO8PBr2
化学文摘社编号:
分子量:
919.88
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
16:0-18:0 (11-12BR) PC, 1-palmitoyl-2-(11,12-dibromo)stearoyl-sn-glycero-3-phosphocholine, powder
InChI
1S/C42H82Br2NO8P/c1-6-8-10-12-13-14-15-16-17-18-21-24-28-32-41(46)50-36-38(37-52-54(48,49)51-35-34-45(3,4)5)53-42(47)33-29-25-22-19-20-23-27-31-40(44)39(43)30-26-11-9-7-2/h38-40H,6-37H2,1-5H3/t38-,39?,40?/m1/s1
InChI key
MPQPFPFIGLVSQR-YXGYHMDESA-N
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCC(Br)C(Br)CCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (850482P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850482P
lipid type
phospholipids
omega FAs
shipped in
dry ice
storage temp.
−20°C
Application
16:0-18:0 (11-12BR) PC (1-palmitoyl-2-(11,12-dibromo) stearoyl-sn-glycero-3-phosphocholine) has been used in large unilamellar vesicle preparation. It may be used:
- in phospholipid vesicle preparation for tryptophan (Trp) penetration depth experiments
- to determine the bromination effect at different positions along the fatty acid chains
- in large unilamellar vesicle (LUV) for quenching of human heat shock protein 70 (Hsp70) tryptophan (Trp) fluorescence
Biochem/physiol Actions
16:0-18:0 (11-12BR) PC (1-palmitoyl-2-(11,12-dibromo) stearoyl-sn-glycero-3-phosphocholine) can be used to prepare large unilamellar vesicles.
General description
16:0-18:0 (11-12BR) PC (1-palmitoyl-2-(11,12-dibromo) stearoyl-sn-glycero-3-phosphocholine) is a brominated-PC lipid which has palmitoyl and stearoyl chains.
Packaging
5 mL Clear Glass Sealed Ampule (850482P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Ajay K Mahalka et al.
Biochimica et biophysica acta, 1838(5), 1344-1361 (2014-02-01)
While a significant fraction of heat shock protein 70 (Hsp70) is membrane associated in lysosomes, mitochondria, and the outer surface of cancer cells, the mechanisms of interaction have remained elusive, with no conclusive demonstration of a protein receptor. Hsp70 contains
Tim Rasmussen et al.
Journal of molecular biology, 431(17), 3339-3352 (2019-06-08)
All membrane proteins have dynamic and intimate relationships with the lipids of the bilayer that may determine their activity. Mechanosensitive channels sense tension through their interaction with the lipids of the membrane. We have proposed a mechanism for the bacterial
Henriette Aksnes et al.
The Journal of biological chemistry, 292(16), 6821-6837 (2017-02-16)
Nα-Acetyltransferase 60 (Naa60 or NatF) was recently identified as an unconventional N-terminal acetyltransferase (NAT) because it localizes to organelles, in particular the Golgi apparatus, and has a preference for acetylating N termini of the transmembrane proteins. This knowledge challenged the
Candace M Pfefferkorn et al.
Biochimica et biophysica acta, 1848(11 Pt A), 2821-2828 (2015-08-25)
Apolipoproteins are essential human proteins for lipid metabolism. Together with phospholipids, they constitute lipoproteins, nm to μm sized particles responsible for transporting cholesterol and triglycerides throughout the body. To investigate specific protein-lipid interactions, we produced and characterized three single-Trp containing
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