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Merck
CN

850469C

Avanti

18:0-20:4 PC

Avanti Research™ - A Croda Brand

别名:

1-十八烷酰基-2-花生四烯-sn-甘油-3-磷酸胆碱；PC(18:0/20:4(5Z,8Z,11Z,14Z))

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关于此项目

经验公式（希尔记法）:
C46H84NO8P
化学文摘社编号:
35418-59-8
分子量:
810.13
MDL number:
MFCD00082436
UNSPSC Code:
51191904
NACRES:
NA.25

主要文件

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产品名称

18:0-20:4 PC, 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine, chloroform

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C46H84NO8P/c1-6-8-10-12-14-16-18-20-22-23-25-27-29-31-33-35-37-39-46(49)55-44(43-54-56(50,51)53-41-40-47(3,4)5)42-52-45(48)38-36-34-32-30-28-26-24-21-19-17-15-13-11-9-7-2/h14,16,20,22,25,27,31,33,44H,6-13,15,17-19,21,23-24,26,28-30,32,34-43H2,1-5H3/b16-14-,22-20-,27-25-,33-31-/t44-/m1/s1

InChI key

PSVRFUPOQYJOOZ-QNPWAGBNSA-N

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850469C-25mg)
pkg of 2 × 4 mL (850469C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850469C

concentration

10 mg/mL (850469C-25mg)
25 mg/mL (850469C-200mg)

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

相关类别

Application

18:0-20:4 PC适用于：
  • 制备脂质体
  • 合成甘油二酯
  • 作为底物测定磷脂酶A2 (PLA2)的活性

Biochem/physiol Actions

18:0-20:4磷脂酰胆碱(PC)在突触囊泡等特殊膜中更为突出。磷脂酰胆碱是真核膜的主要甘油磷脂之一。它对于维持膜的结构和功能至关重要。Pc是各种第二信使的前体，例如磷脂酸，溶血磷脂酸，二酰基甘油。

General description

磷脂酰胆碱(PC)在sn-1位置有饱和(18:0)链，在sn-2位置有不饱和(20:4)链。PC的不对称组合在哺乳动物脂质中很常见。PC是两性离子磷脂。PC是通过Kennedy途径从胆碱合成的。

Packaging

5 mL透明玻璃密封安瓿（850469C-200mg）
5 mL透明玻璃密封安瓿（850469C-25mg）

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

易制毒化学品（2类）
危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2
Han SK, et al.
Journal of biological and chemical chronicles, 274(17), 11881-11888 (1999)
Acyl chain dependence of diacylglycerol activation of protein kinase C activity in vitro
Marignani PA, et al.
Biochemical and Biophysical Research Communications, 225(2), 469-473 (1996)
Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage
Manni M M, et al.
eLife, 7, e34394-e34394 (2018)
The Kennedy pathway?de novo synthesis of phosphatidylethanolamine and phosphatidylcholine
Gibellini F and Smith TK
IUBMB Life, 62(6), 414-428 (2010)
Warren G Hill et al.
American journal of physiology. Cell physiology, 289(1), C33-C41 (2005-02-25)
Caveolae are invaginated membrane structures with high levels of cholesterol, sphingomyelin, and caveolin protein that are predicted to exist as liquid-ordered domains with low water permeability. We isolated a caveolae-enriched membrane fraction without detergents from rat lung and characterized its

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