检测方案
>99% (TLC)
形式
powder
包装
pkg of 2 × 100 mg (850468P-200mg)
pkg of 1 × 25 mg (850468P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 850468P
脂质类型
phospholipids
cardiolipins
运输
dry ice
储存温度
−20°C
SMILES字符串
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
InChI
1S/C44H84NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h15,17,21,23,42H,6-14,16,18-20,22,24-41H2,1-5H3/b17-15-,23-21-/t42-/m1/s1
InChI key
FORFDCPQKJHEBF-VPUSDGANSA-N
一般描述
18:0-18:2磷脂酰胆碱（PC）在sn-1位置具有饱和脂肪酸，在sn-2位置具有不饱和脂肪酸，在sn-3位置具有含磷酸盐的极性基团。PC是两性离子磷脂。PC是通过Kennedy途径从胆碱合成的。
应用
18:0-18:2 PC适用于：
- 制备巨大的单层囊泡
- 制备脂质体
- 以2，2′-偶氮双（2-脒基丙烷）二盐酸盐（AAPH）制备氧化磷脂，用于多反应监测（MRM）分析
生化/生理作用
磷脂酰胆碱是真核膜的主要甘油磷脂之一。它对于维持膜的结构和功能至关重要。PC是鞘磷脂合成的底物。Pc是各种第二信使的前体，例如磷脂酸，溶血磷脂酸，二酰基甘油。
包装
5 mL透明玻璃密封安瓿（850468P-200mg）
5 mL透明玻璃密封安瓿（850468P-25mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Development of oxidized phosphatidylcholine isomer profiling method using supercritical fluid chromatography/tandem mass spectrometry
Uchikata T, et al.
Journal of Chromatography A, 1250(2), 205-211 (2012)
A Arora et al.
Archives of biochemistry and biophysics, 373(1), 102-109 (2000-01-06)
The polyphenolic structures of flavonoids and isoflavonoids confer them with the ability to scavenge free radicals and to chelate transition metals, a basis for their potent antioxidant abilities. Another possible contributory mechanism toward their antioxidant activities is their ability to
Z Djuric et al.
Journal of biochemical and molecular toxicology, 15(2), 114-119 (2001-04-03)
Lipid and DNA oxidation catalyzed by iron(II) were compared in HEPES and phosphate buffers. Lipid peroxidation was examined in a sensitive liposome system constructed with a fluorescent probe that allowed us to examine the effects of both low and high
The Kennedy pathway?de novo synthesis of phosphatidylethanolamine and phosphatidylcholine
Gibellini F and Smith TK
IUBMB Life, 62(6), 414-428 (2010)
Wenbo Cao et al.
Analytical chemistry, 90(17), 10286-10292 (2018-08-11)
The presence of carbon-carbon double bonds (C═Cs) in unsaturated phospholipids is closely related to lipid conformations and physiochemical activities. Previously, we have demonstrated that epoxidation reaction facilitated by low-temperature plasma (LTP) enabled the structural analysis of unsaturated fatty acids (FAs).
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