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主要文件

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安全信息

850400C

Avanti

22:6 (Cis) PC

1,2-didocosahexaenoyl-sn-glycero-3-phosphocholine, chloroform

别名:

1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine; PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

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About This Item

经验公式（希尔记法）:
C52H80NO8P
CAS号:
99296-81-8
分子量:
878.17
MDL编号:
MFCD00674317
UNSPSC代码:
51191904
NACRES:
NA.25

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 2.5 mL (850400C-25mg)
pkg of 5 × 4 mL (850400C-500mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 850400C

浓度

10 mg/mL (850400C-25mg)
25 mg/mL (850400C-500mg)

脂质类型

cardiolipins
phospholipids

运输

dry ice

储存温度

−20°C

SMILES字符串

[P](=O)([O-])(OC[C@H](OC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)COC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)OCC[N+](C)(C)C

InChI

1S/C52H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h8-11,14-17,20-23,26-29,32-35,38-41,50H,6-7,12-13,18-19,24-25,30-31,36-37,42-49H2,1-5H3/b10-8-,11-9-,16-14-,17-15-,22-20-,23-21-,28-26-,29-27-,34-32-,35-33-,40-38-,41-39-/t50-/m1/s1

InChI key

XLKQWAMTMYIQMG-SVUPRYTISA-N

相关类别

一般描述

22:6 (cis) PC or 1,2-didocosahexaenoyl-sn-glycero-3-phosphocholine is an unsaturated glycerophospholipid, with substitution of two chains of docosahexaenic acid at sn-1 and sn-2 positions of the glycerol backbone, along with choline as a headgroup. It is an omega-3 lipid.

应用

22:6 (cis) PC or 1,2-didocosahexaenoyl-sn-glycero-3-phosphocholine might be used:
  • in liposomes, to study its effect on membrane vesiculation by dynamin and endophilin
  • in multi-lamellar vesicles (MLVs) to analyze its effect on the biophysical properties of lipid membranes and on its interaction with a fragment of the Aβ peptide
  • in lipid bilayers to study the influence of cholesterol on lateral segregation of saturated and unsaturated phospholipids

包装

5 mL Clear Glass Sealed Ampule (850400C-25mg)
5 mL Clear Glass Sealed Ampule (850400C-500mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

危险化学品
易制毒化学品（2类）

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Giuseppe Vitiello et al.
Langmuir : the ACS journal of surfaces and colloids, 29(46), 14239-14245 (2013-10-23)
Polyunsaturated omega-3 fatty acids are increasingly proposed as dietary supplements able to reduce the risk of development or progression of the Alzheimer's disease (AD). To date, the molecular mechanism through which these lipids act has not been yet univocally identified.
Oskar Engberg et al.
Biophysical journal, 111(3), 546-556 (2016-08-11)
Saturated and unsaturated phospholipids (PLs) can segregate into lateral domains. The preference of cholesterol for saturated acyl chains over monounsaturated, and especially polyunsaturated ones, may also affect lateral segregation. Here we have studied how cholesterol influenced the lateral segregation of
Marco M Manni et al.
eLife, 7 (2018-03-16)
Phospholipid membranes form cellular barriers but need to be flexible enough to divide by fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas the sn2-FA is saturated, monounsaturated or polyunsaturated. Our understanding of the impact of
Philippe Calvez et al.
Journal of the American Chemical Society (2016-10-01)
Recoverin undergoes a calcium-myristoyl switch during visual phototransduction. Indeed, calcium binding by recoverin results in the extrusion of its myristoyl group, which allows its membrane binding. However, the contribution of particular lipids and of specific amino acids of recoverin in

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