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检测方案
>99% (TLC)
形式
liquid
包装
pkg of 1 × 2.5 mL (850395C-25mg)
pkg of 2 × 4 mL (850395C-200mg)
制造商/商品名称
Avanti Polar Lipids 850395C
浓度
10 mg/mL (850395C-25mg)
25 mg/mL (850395C-200mg)
脂质类型
cardiolipins
phospholipids
运输
dry ice
储存温度
−20°C
一般描述
18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine is an unsaturated glycerophospholipid, with substitution of two chains of linolenic acid at sn-1 and sn-2 positions of the glycerol backbone, along with choline as a headgroup.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
应用
18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine:
- might be used in aqueous lipid-trehalose formulations to assess the long-term storage stability of lyophilized liposomes
- might be used in phospholipid monolayer to study the instability of unsaturated phospholipids at specified conditions
- has been used in aqueous sugar formulations or liposome formulations to characterize its degradation during lyophilization
包装
5 mL Clear Glass Sealed Ampule (850395C-200mg)
5 mL Clear Glass Sealed Ampule (850395C-25mg)
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system, Liver,Kidney
WGK
WGK 3
法规信息
危险化学品
易制毒化学品（2类）
Jonathan F D Liljeblad et al.
Biophysical journal, 98(10), L50-L52 (2010-05-21)
The surface specific technique vibrational sum frequency spectroscopy has been applied to in situ studies of the degradation of Langmuir monolayers of 1,2-diacyl-phosphocholines with various degrees of unsaturation in the aliphatic chains. To monitor the degradation of the phospholipids, the
N M Payton et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 85(2), 306-313 (2013-04-10)
As liquid liposomal formulations are prone to chemical degradation and aggregation, these formulations often require freeze drying (e.g., lyophilization) to achieve sufficient shelf-life. However, liposomal formulations may undergo oxidation during lyophilization and/or during prolonged storage. The goal of the current
Nicole M Payton et al.
Journal of pharmaceutical sciences, 103(12), 3869-3878 (2014-10-14)
Because aqueous liposomal formulations containing multiply unsaturated lipids are susceptible to chemical degradation, these formulations are often lyophilized. Despite their limited chemical stability, interest in the use of multiply unsaturated lipids to promote intracellular delivery has increased considerably in recent
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