所有图片(2)
别名:
1,2-dipetroselinoyl-sn-glycero-3-phosphocholine; PC(18:1(6Z)/18:1(6Z))
经验公式（希尔记法）:
C44H84NO8P
推荐产品
检测方案
>99% (TLC)
形式
liquid
包装
pkg of 1 × 2.5 mL (850374C-25mg)
制造商/商品名称
Avanti Polar Lipids 850374C
浓度
10 mg/mL (850374C-25mg)
脂质类型
phospholipids
cardiolipins
运输
dry ice
储存温度
−20°C
一般描述
18:1 (Δ6-Cis) PC (1,2-dipetroselenoyl-sn-glycero-3-phosphocholine) is a lipid derivative having a phosphocholine backbone. It also has two18 carbon fatty acid chains, each having one cis double bond at the 6th carbon.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
应用
18:1 (Δ6-Cis) PC (1,2-dipetroselenoyl-sn-glycero-3-phosphocholine) may be used:
- to generate sn-1 C18:1(Δ6-cis)- lysophosphatidylcholine (LPC) and sn-1 C18:1(Δ9-cis)-LPC standards for structural characterization of lysophosphatidylcholine (LPC) species by tandem electrospray ionization-linear ion trap-mass spectrometry (ESI-LIT-MS)
- to study the effect on α-secretase activityin SH-SY5Y membrane
- in liposome to study the effect of its acyl chain length and bond saturation on pore formation
生化/生理作用
Phosphatidylcholine (PC) can form a hydrophobic surface in the mucus by acting as a surfactant to inhibit the penetrance of bacteria.
包装
5 mL Clear Glass Sealed Ampule (850374C-25mg)
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system, Liver,Kidney
WGK
WGK 3
法规信息
危险化学品
易制毒化学品（2类）
Inflammatory Bowel Disease
Integrative Medicine, 501-516 (2018)
Koldo Morante et al.
The Journal of biological chemistry, 290(17), 10850-10861 (2015-03-12)
The physicochemical landscape of the bilayer modulates membrane protein function. Actinoporins are a family of potent hemolytic proteins from sea anemones acting at the membrane level. This family of cytolysins preferentially binds to target membranes containing sphingomyelin, where they form
Felipe Gazos-Lopes et al.
PLoS neglected tropical diseases, 8(8), e3077-e3077 (2014-08-08)
Trypanosoma cruzi is the causative agent of the life-threatening Chagas disease, in which increased platelet aggregation related to myocarditis is observed. Platelet-activating factor (PAF) is a potent intercellular lipid mediator and second messenger that exerts its activity through a PAF-specific
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
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