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检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 g (850337P-1g)
pkg of 1 × 5 g (850337P-5g)
制造商/商品名称
Avanti Polar Lipids 850337P
运输
dry ice
储存温度
−20°C
InChI
1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
InChI key
PQLXHQMOHUQAKB-UHFFFAOYSA-N
一般描述
Hexadecylphosphocholine is a structural analog of palmitoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification. It has been shown to have antineoplastic and antiprotozoal activity.
应用
MAPCHO®-16 has been used to test against Leishmania intracellular amastigotes. It has also been use to evaluate its efficacy in L. infantum chagasi infections.
生化/生理作用
MAPCHO®-16/ n-hexadecylphosphocholine/Miltefosine can be used as a stationary phase to determine total acidity of divalent cations by ion chromatography. It is used in the oral treatment of human leishmaniasis
包装
20 mL Clear Glass Screw Cap Vial (850337P-1g)
60 mL Amber Wide Mouth Glass Bottle with Screw Cap (850337P-5g)
法律信息
MAPCHO is a registered trademark of Avanti Polar Lipids, Inc.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 3
Combination therapy with nitazoxanide and amphotericin B, Glucantime, miltefosine and sitamaquine against Leishmania (Leishmania) infantum intracellular amastigotes
Mesquita JT, et al.
Acta Tropica, 130, 112-116 (2014)
Synthesis of 16-mercaptohexadecylphosphocholine, a miltefosine analog with leishmanicidal activity
Hornillos V, et al.
Bioorganic & medicinal chemistry letters, 16(19), 5190-5193 (2006)
Determination of total acidity and of divalent cations by ion chromatography with n-hexadecylphosphocholine as the stationary phase
Hu W, et al.
Journal of Chromatography A, 956(1-2), 139-145 (2002)
Juliana Q Reimão et al.
PLoS neglected tropical diseases, 9(2), e0003556-e0003556 (2015-02-14)
The only oral drug available for the treatment of leishmaniasis is miltefosine, described and approved for visceral leishmaniasis in India. Miltefosine is under evaluation for the treatment of cutaneous leishmaniasis in the Americas although its efficacy for the treatment of
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