描述
n-dodecylphosphocholine
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 g (850336P-1g)
pkg of 1 × 25 g (850336P-25g)
pkg of 1 × 5 g (850336P-5g)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
InChI
1S/C17H38NO4P/c1-5-6-7-8-9-10-11-12-13-14-16-21-23(19,20)22-17-15-18(2,3)4/h5-17H2,1-4H3
InChI key
QBHFVMDLPTZDOI-UHFFFAOYSA-N
一般描述
MAPCHO™-12 或正十二烷基磷酸胆碱是短链去污剂。
十二烷基磷酸胆碱是月桂酰溶血磷脂酰胆碱的结构类似物，其对水解降解更稳定。该脂质通常用作膜蛋白溶解和纯化的去污剂。研究表明十二烷基磷酸胆碱可通过调节紧密连接来改善亲水性化合物的细胞旁通透性。这可能对其用于口服或鼻腔给药有影响。
应用
MAPCHO™-12 适合用作核磁共振实验中枯草芽孢杆菌细胞色素 b558 蛋白的去污剂 。它也适用于gp41（gp41CT）蛋白的细胞质尾的纯化和胶束制备。
生化/生理作用
MAPCHO-12™ 或正十二烷基磷酸胆碱与 1,2-二肉豆蔻酰基-sn-甘油-3-磷酸胆碱（DMPC）结合可用于膜模拟 bicelle 系统，用于基于方向的膜蛋白研究。它在膜胶束结构中提供了两性离子表面。
包装
125 mL 带螺旋盖的琥珀色宽口玻璃瓶（850336P-5g）
20 mL 透明玻璃螺旋盖小瓶（850336P-1g）
250 mL 带螺旋盖的琥珀色宽口玻璃瓶（850336P-25g）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Nolandt OV, et al.
Biochimica et Biophysica Acta - Biomembranes, 1818(5), 1142-1147 (2012)
Nina Liu et al.
Heliyon, 5(12), e03018-e03018 (2020-01-01)
Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined "class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the fusion subunit (e.g., GP2 for
Thermodynamics, size, and dynamics of zwitterionic dodecylphosphocholine and anionic sodium dodecyl sulfate mixed micelles
Sikorska E, et al.
Journal of Thermal Analysis and Calorimetry, 123(1), 511-523 (2016)
Solution structure and membrane interaction of the cytoplasmic tail of HIV-1 gp41 protein
Murphy RE, et al.
Structure, 25(11), 1708-1718 (2017)
Sheeja V Vasudevan et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(15), 6847-6851 (2010-03-31)
Repair of damage to the central nervous system (CNS) is inhibited by the presence of myelin proteins that prevent axonal regrowth. Consequently, growth inhibitors and their common receptor have been identified as targets in the treatment of injury to the
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