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经验公式（希尔记法）:
C24H48NO8P
化学文摘社编号:
分子量:
509.61
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
08:0 PC, 1,2-dioctanoyl-sn-glycero-3-phosphocholine, powder
InChI key
YHIXRNNWDBPKPW-JOCHJYFZSA-N
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC)=O)COC(CCCCCCC)=O)=O
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 200 mg (850315P-200mg), pkg of 1 × 25 mg (850315P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850315P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
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General description
Phosphatidylcholine (PC) is one of the most important constituent of the mucosal layer of the colon. 08:0 PC (1,2-dioctanoyl-sn-glycero-3-phosphocholine/C8PC) is a water soluble short alkyl chain lipid.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Application
08:0 PC (1,2-dioctanoyl-sn-glycero-3-phosphocholine/C8PC) has been used as a substrate to study the analytical capabilities of several methods to determine water soluble phospholipids containing choline (wCh-PL) and also to study the behavior of the its analytical signal in a synthetic serum matrix (data-Trol). It may also be used as a bicellar model to study their phase behavior and to form a lipid film to study its effect on P-glycoprotein′s (P-gp′s) activity/to compare its effect.
Biochem/physiol Actions
Phosphatidylcholine (PC) can form a hydrophobic surface in the mucus by acting as a surfactant to inhibit the penetrance of bacteria.
Packaging
20 mL Clear Glass Screw Cap Vial (850315P-200mg)
5 mL Clear Glass Sealed Ampule (850315P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Phase behavior of a binary lipid system containing long- and short-chain phosphatidylcholines
Sun HY, et al.
Royal Society of Chemistry Advances, 7(10), 5715-5724 null
Manuel Weinheimer et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 108, 13-22 (2016-09-04)
The efflux transporter P-glycoprotein (P-gp) significantly modulates drug transport across the intestinal mucosa, strongly reducing the systemic absorption of various active pharmaceutical ingredients. P-gp inhibitors could serve as helpful tools to enhance the oral bioavailability of those substances. As a
Isabel Sanz-Vicente et al.
Analytical biochemistry, 519, 30-37 (2016-12-14)
In this paper we present methods to determine water soluble phospholipids containing choline (wCh-PL). The analytes were hydrolyzed by the enzyme phospholipase D and the choline formed was oxidized by the enzyme Choline Oxidase (ChOx); the fluorescence changes of the
Inflammatory Bowel Disease
Integrative Medicine, 501-516 null
Teruhiko Baba et al.
Chemistry and physics of lipids, 227, 104870-104870 (2020-01-10)
Interfacial properties and membrane protein solubilization activity of a series of partially fluorinated octyl-phosphocholine (PC) surfactants were investigated from the viewpoint of the fluorination degree of the hydrophobic chain. The critical micelle concentration (CMC), surface tension lowering activity, molecular occupied
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